Table 2

Cytokines and related indicators included in every study

Author	Cytokine	Reference test	Diagnostic test	TP	FN	FP	TN	Cut-off value (pg/mL)
Won	TNF-α	IGRA	Luminex	21	15	1	14	373.6
Won	IL-10	IGRA	Luminex	23	13	3	12	0.145
Wu	IFN-γ	IGRA	Luminex	13	12	4	32	1600
	TNF-α			20	5	17	19	1576
	IL-2			21	4	15	21	976.3
	IL-10			20	5	15	21	251
	IP-10			19	6	12	24	1139
Jeong	IFN-γ	TST	Luminex	18	2	8	25	172.84
Jeong	IP-10	TST	Luminex	17	3	3	30	23 780
Clifford	IFN-γ	TST and IGRA	Luminex	34	4	9	34	1215
	TNF-α			28	10	4	39	332
	IP-10			16	22	4	39	19 301
	IL-2			33	5	8	35	398
Kim	IFN-γ	TST and IGRA	ELISA	20	8	6	16	None
	IP-10			28	0	18	4	None
	TNF-α			27	1	12	10	None
Wang	IFN-γ	IGRA	Luminex	18	10	8	26	77.6
	IP-10			13	15	3	31	10 821
	IL-12			15	13	9	25	57.39
	VEGF			15	13	3	31	225.1
Pathakumari	IFN-γ	IGRA	ELISA	8	31	5	30	116.4
	TNF-α			21	18	5	30	381.8
	IL-12			15	24	5	30	171.4
Hur	TNF-α	IGRA	ELISA	38	14	9	22	302.2
Zhang	IFN-γ	IGRA	FluoroSpot	24	2	9	36	248
La Manna	IFN-γ	IGRA	Luminex	19	8	3	29	124
	IP-10			22	5	5	27	637
	IL-2			22	5	2	30	90
	IL-12			15	12	4	28	6
You	IP-10	IGRA	ELISA	29	11	12	28	1587.76
	IL-2			23	17	16	24	106.51
	IL-10			34	6	19	21	0.18
Suzukawa	TNF-α	IGRA	Luminex	10	21	2	27	660.6
	IP-10			23	8	14	15	33 082
	IL-2			30	1	22	7	333.2
	IL-10			20	11	3	26	0.8
	IL-12			17	14	6	23	10.3
	VEGF			8	23	2	27	23.4
Yao	IP-10	IGRA	Luminex	10	10	1	14	1580
Yao	VEGF	IGRA	Luminex	17	3	4	11	37.54
Wang	IP-10	IGRA	ELISA	59	7	42	31	451.3
Wang	IL-2	IGRA	ELISA	57	9	29	44	13.1

FN, false negative; FP, false positive; IGRA, interferon-gamma release assay; TN, true negative; TP, true positive; TST, tuberculin skin test.