Table 3

Influence of age, body mass index (BMI|), duration of surgery and applied driving pressure on central venous pressure and cardiac index in a multivariable analysis

Dependent variable	Independent variable	Slope (95% CI)	P value
	Age	0.09 (−0.11 to, 0.29)	0.38
	BMI	−0.20 (−0.61 to 0.21)	0.33
	Duration of surgery	0.24 (−17.96 to 18.43)	0.98
	Driving pressure	0.63 (0.41 to 0.86)	<0.001*
Central venous pressure	Time points:
	T1	Reference
	T2	11.52 (8.17 to 14.86)	<0.001*
	T3	13.83 (9.99 to 17.67)	<0.001*
	T4	14.09 (9.89 to 18.29)	<0.001*
	T5	1.93 (−0.38 to 4.24)	0.1
	Age	0.003 (−0.02 to 0.02)	0.77
	BMI	0.01 (−0.03 to 0.05)	0.67
	Duration of surgery	1.89 (0.09 to 3.59)	0.04*
	Driving pressure	−0.01 (−0.03 to 0.01)	0.52
	Noradrenalin	−0.52 (−2.01 to 0.98)	0.5
Cardiac Index	Time points:
	T1	Reference
	T2	0.36 (0.05 to 0.66)	0.022*
	T3	0.54 (0.17 to 0.90)	0.004*
	T4	0.46 (0.06 to 0.86)	0.025*
	T5	0.66 (0.42 to 0.89)	<0.001*

95% CI, BMI, T1: 20 min after induction of anaesthesia, T2: after insufflation of capnoperitoneum in supine position, T3: after 30 min in steep Trendelenburg position (STP), T4: when controlling Santorini’s plexus in STP, T5: after the laparoscopic procedure while in supine position before the end of anaesthesia; #patient-related, surgical-related, ventilatory and time-related confounders for multivariable analysis for haemodynamic parameter of cardiac preload and contractility.
*P<0.05.