Table 1

Schedule of enrolment, interventions and assessments

Timepoint
(weeks)
EnrolmentBaseline
assessment
Post-intervention assessment
T-6T-4T0T1T2T8T16 (closeout)
Enrolment
 Eligibility screenX
 Informed consentX
Interventions
 CEUSSX
Assessments
 SafetyXXXX
 Technical feasibility and applicabilityX
 UWSF, SWSF and SPSFXXXXXX
 Analysis of the salivary cytokine profilesXXXXX
 CODSXXXXX
 XI scoreXXXXX
 ESSPRI scoreXXXXX
 MPQXXXXX
 Salivary gland topographyXXX
  • CEUSS, contrast-enhanced ultrasound sialendoscopy; CODS, Clinical Oral Dryness Score; ESSPRI, European League Against Rheumatism (EULAR) Sjögren’s Syndrome Patient Reported Index; MPQ, McGill Pain Questionnaire; SPSF, stimulated parotid saliva flow; SWSF, stimulated whole mouth saliva flow; T-6, 6 weeks before intervention; UWSF, unstimulated whole mouth saliva flow; XI, Xerostomia Inventory.