Table 1

Schedule of enrolment, interventions and assessments

Timepoint (weeks)	Enrolment	Baseline assessment	Post-intervention assessment
Timepoint (weeks)	T-6	T-4	T0	T1	T2	T8	T16 (closeout)
Enrolment
Eligibility screen	X
Informed consent		X
Interventions
CEUSS			X
Assessments
Safety				X	X	X	X
Technical feasibility and applicability			X
UWSF, SWSF and SPSF	X	X		X	X	X	X
Analysis of the salivary cytokine profiles		X		X	X	X	X
CODS		X		X	X	X	X
XI score		X		X	X	X	X
ESSPRI score		X		X	X	X	X
MPQ		X		X	X	X	X
Salivary gland topography		X		X			X

CEUSS, contrast-enhanced ultrasound sialendoscopy; CODS, Clinical Oral Dryness Score; ESSPRI, European League Against Rheumatism (EULAR) Sjögren’s Syndrome Patient Reported Index; MPQ, McGill Pain Questionnaire; SPSF, stimulated parotid saliva flow; SWSF, stimulated whole mouth saliva flow; T-6, 6 weeks before intervention; UWSF, unstimulated whole mouth saliva flow; XI, Xerostomia Inventory.