Objective/analyses | Outcome | Method of analysis | Independent variables | |
Primary objective | Definition | Type | ||
To determine which clinical and continuity of care variables predict the outcome in senior OAC users post-hospitalisation. | Re-hospitalisation or ED visit for a haemorrhagic or thromboembolic event or mortality in 30 days. | Time to event. | Cox proportional hazards model. | Demographic
Index hospitalisation characteristics
Type of OAC user.
Comorbidities
Indications
Potential drug interactions
Continuity of care
|
Sensitivity analyses | ||||
Include myocardial infarction in the definition of thromboembolic event outcome. | Re-hospitalisation or ED visit for a haemorrhagic or thromboembolic event or mortality in 30 days. | Time to event. | Cox proportional hazards model. | |
Competing risk analysis. | Re-hospitalisation or ED visit for a haemorrhagic or thromboembolic event in 30 days. | Time to event. | Cause-specific Cox proportional hazards model. | |
Validation | ||||
Internal validation of the primary model. | Re-hospitalisation or ED visit for a haemorrhagic or thromboembolic event or mortality in 30 days. | Time to event. | Split-sample method. |
*Over-the-counter use of drug is not captured.
CHA2DS2-VASc, congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke, vascular disease, age 65–74 years, sex category; ED, emergency department; HAS-BLED, hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalised ratio (excluded), elderly (>65 years), drugs/alcohol concomitantly; NSAIDs, non-steroidal anti-inflammatory drugs; OAC, oral anticoagulant; SSRIs, selective serotonin reuptake inhibitors.