Summary of ethical amendments
| Protocol | Date | Summary of changes |
| V2 | 16 October 2018 | Re-formatting of consent forms to fit within one A4 page (minor). |
| V2.1 | 29 March 2019 | Amendment to letters informing/seeking guidance from participants’ general practitioner regarding potential contraindications for nicotine replacement therapy and requesting varenicline prescriptions. |
| Minor amendments to interview topic guides. | ||
| Change to incentive amounts. | ||
| Audio recording of a sample of initial consultation interactions (substantial). | ||
| V2.2 | 03 June 2019 | Change timing of consent to YESS trial—not implemented. |
| V2.1 | 26 July 2019 | Submission of YESS subsection 1 and 2 participant information sheet (V.1 17 05 2019) as they were omitted from the original application (substantial). |
| V2.2 | 11 November 2019 | Reduction in recruitment target from 2019 to 1040 to reflect the number of smokers enrolling in YLST (substantial). |
YESS, Yorkshire Enhanced Stop Smoking; YLST, Yorkshire Lung Screening Trial.