Table 1

Participant characteristics for live births 22–27 weeks gestation who received intensive care across eras

Era
1991–1992
n=332
1997
n=190
2005
n=229
2016–2017*
n=250
OR or mean diff. (95% CI), p valueOR or mean diff.(95% CI), p valueOR or mean diff. (95% CI), p value
Born in a tertiary perinatal centre300 (90.4)1.65 (0.98 to 2.78), p=0.06177 (93.2)2.32 (1.18 to 4.56), p=0.02199 (86.9)1.20 (0.69 to 2.08), p=0.52211 (84.4)
Multiple birth95 (28.6)0.97 (0.62 to 1.53), p=0.9039 (20.5)0.63 (0.34 to 1.16), p=0.1457 (24.9)0.80 (0.48 to 1.35), p=0.4173 (29.2)
Antenatal corticosteroids220 (66.3)0.30 (0.19 to 0.47), p<0.001165 (86.8)1.03 (0.57 to 1.84), p=0.93193 (84.3)0.83 (0.49 to 1.42), p=0.50215/249 (86.3)
Caesarean birth78/331 (23.6)0.24 (0.16 to 0.34), p<0.001101 (53.2)0.75 (0.50 to 1.12), p=0.16122 (53.3)0.84 (0.57 to 1.23), p=0.36149 (59.6)
Gestation at birth (completed weeks), mean (SD)25.6 (1.2)0.1 (−0.1 to 0.3), p=0.3825.5 (1.2)0.0 (−0.3 to 0.2), p=0.7825.5 (1.3)0.0 (−0.2 to 0.3), p=0.9325.6 (1.3)
Male183 (55.1)1.06 (0.75 to 1.49), p=0.75110 (57.9)1.18 (0.79 to 1.75), p=0.44122 (53.3)0.98 (0.68 to 1.43), p=0.92134 (53.6)
Birth weight (g), mean (SD)862 (179)25 (−8 to 57), P=0.14802 (188)−29 (−68 to 9), p=0.13824 (205)−12 (−50 to 26), p=0.54836 (196)
Birth weight z-score, mean (SD)0.07 (1.01)0.11 (−0.06 to 0.28), p=0.21−0.25 (0.99)−0.19 (−0.39 to 0.00), p=0.05−0.13 (0.97)−0.10 (−0.28 to 0.09), p=0.30−0.05 (0.98)
Intubated at birth308/331 (93.1)9.05 (5.48 to 14.9), p<0.001181/189 (95.8)14.5 (6.79 to 30.9), p<0.001183 (79.9)2.80 (1.82 to 4.30), p<0.001147 (58.8)
  • Data are n (%) unless otherwise specified.

  • *2016–2017 cohort as a reference for all comparisons.