Table 1

Study timeline and investigations

Written informed consentScreening/Baseline4 months8 months
Eligibility checkx
Clinical history, ethnicity and medicationsx
Heightx
Weightxxx
Waist circumferencexxx
Hip circumferencexxx
Blood pressurexxx
Laboratory Test*xxx
Sample for DNA extraction†x
C-peptidex
Diabetes autoantibodiesx
Medication dispensingxx
Medication return and accountabilityxxx
DTSQs‡xxx
DTSQc§x
Patient-reported side effectsxx
Patient overall study medication preferencex
  • *blood sample for creatinine, lipid profile, liver enzymes, glucose, HbA1c

  • †Genotyping for CREBRF and other genetic variants associated with glucose lowering response to diabetes medications

  • ‡Diabetes treatment satisfaction questionnaire (status version)

  • §Diabetes treatment satisfaction questionnaire (change version)