Characteristics of sample by POSAMINO exposure
| POSAMINO exposure | Total (%) (n=1599) | P value | ||
| No POSAMINO (n=1156; 72%) | One or more POSAMINO (n=443; 28%) | |||
| Gender | ||||
| Male | 445 (39%) | 270 (61%) | 715 (45) | <0.001 |
| Female | 711 (61%) | 173 (39%) | 884 (55) | |
| Age (years) | ||||
| 65–69 | 217 (19%) | 111 (25%) | 328 (21) | <0.001 |
| 70–74 | 301 (26%) | 135 (30%) | 436 (27) | |
| 75–79 | 305 (26%) | 105 (24%) | 410 (26) | |
| 80+ | 333 (29%) | 92 (21%) | 425 (27) | |
| Area | ||||
| Rural | 283 (25%) | 87 (20%) | 370 (23) | 0.03 |
| Urban | 857 (75%) | 355 (80%) | 1212 (77) | |
| Relationship status | ||||
| Married/partner | 619 (54%) | 271 (62%) | 890 (56) | 0.02 |
| Single/separated/divorced | 211 (19%) | 75 (17%) | 286 (18) | |
| Widowed | 311 (27%) | 93 (21%) | 404 (26) | |
| Education status | ||||
| None/primary | 354 (31%) | 152 (35%) | 506 (32) | 0.17 |
| Secondary school | 482 (43%) | 164 (38%) | 646 (41) | |
| Third level | 299 (26%) | 123 (28%) | 422 (27) | |
| Self-rated health | ||||
| Excellent to very good | 370 (32%) | 108 (24%) | 478 (30) | 0.01 |
| Good | 458 (40%) | 186 (42%) | 644 (40) | |
| Fair to poor | 325 (28%) | 148 (33%) | 473 (30) | |
| Alcohol consumption* | ||||
| Non-drinker | 534 (46%) | 0 | 534 (33) | <0.001 |
| Current drinker (but not heavy drinker) | 556 (48%) | 74 (17%) | 630 (39) | |
| Heavy drinker | 66 (6%) | 369 (83%) | 435 (27) | |
| Smoking status | ||||
| Current smoker | 111 (10%) | 45 (10%) | 156 (10) | <0.001 |
| Past smoker | 444 (38%) | 227 (52%) | 671 (42) | |
| Never smoked | 600 (52%) | 169 (38%) | 769 (48) | |
| Polypharmacy | ||||
| Yes | 779 (67%) | 344 (78%) | 1123 (70) | <0.001 |
| No | 377 (33%) | 99 (22%) | 476 (30) | |
| Comorbidities† (ICD-10 classification) | ||||
| Diseases of the circulatory system | 1019 (88%) | 415 (94%) | 1434 (90) | <0.001 |
| Diseases of the digestive system | 621 (54%) | 286 (64%) | 907 (57) | <0.001 |
| Diseases of the genitourinary system | 107 (9%) | 64 (14%) | 171 (11) | 0.003 |
| Mental and behavioural disorders | 379 (33%) | 173 (39%) | 552 (35) | 0.02 |
| Endocrine, nutritional and metabolic disorders | 346 (30%) | 117 (29%) | 463 (29) | 0.17 |
| Disease of the musculoskeletal system and connective tissue | 234 (20%) | 90 (20%) | 324 (20) | 0.97 |
| Diseases of the nervous system | 130 (11%) | 71 (16%) | 201 (13) | 0.01 |
| Diseases of the respiratory system | 324 (28%) | 121 (27%) | 445 (28) | 0.02 |
*Alcohol consumption was based on self-reported alcohol consumption in the past 12 months: non-drinkers reported not drinking in the past 12 months; current drinkers (drank alcohol in the past 12 months); heavy drinkers (reported drinking >60 g alcohol per drinking occasion or drinking >110 g alcohol/week for women or >170 g alcohol/week for men).
†Determined by the Rx-Risk tool.
ICD-10, International Classification of Diseases, Tenth Revision; POSAMINO, POtentially Serious Alcohol-Medication INteractions in Older adults.