Table 2

Number and prevalence of POSAMINO criteria among total sample, current drinkers and those using medications included in POSAMINO

Criteria descriptionNumber of people fitting POSAMINO criteria% of total sample
(n=1599)
% of current drinkers
(n=1065)
% taking medication class*
Cardiovascular system2971927.927.9
 Heavy alcohol consumption with multiple antihypertensive combinations1881217.728.0
 Heavy alcohol consumption with warfarin (and phenindione)2722.526.7
 Heavy alcohol consumption with regular use of low dose aspirin (75 mg)2041319.230.4
 Heavy alcohol consumption with both regular and as required nitrates (eg, glyceryl trinitrate, isosorbide dinitrate and isosorbide mononitrate)2112.031.3
 Heavy alcohol consumption with the vasodilatory medication nicorandil0000
 Heavy alcohol consumption with the combined use of both nitrates and vasodilator medication (eg, nicorandil)0000
 Heavy alcohol consumption with diuretics (eg, loop diuretics (furosemide), thiazide diuretics (bendroflumethiazide) and potassium sparing diuretics (amiloride))774.87.225.2
 Heavy alcohol consumption with alpha blockers (eg, terazosin)201.31.927.0
 Heavy alcohol consumption with centrally acting antihypertensives (eg, clonidine or methyldopa)0000
Respiratory system100.60.952.6
 Any alcohol consumption with first generation antihistamines (eg, promethazine)100.60.952.6
Central nervous system2411522.630.4
 Heavy alcohol consumption with benzodiazepines (eg, diazepam) and benzodiazepine-related medications (eg, zopiclone)885.58.324.3
 Heavy alcohol consumption combined with opioids734.66.925.6
 Heavy alcohol consumption with all antipsychotics70.40.714.6
 Heavy alcohol consumption with antiepileptic drugs352.23.323.6
 Any alcohol consumption with tricyclic antidepressants452.84.266.7
 Any alcohol consumption with mirtazapine191.21.855.9
 Any alcohol consumption with monoamine oxidase inhibitors0000
 Heavy alcohol consumption with long-term regular paracetamol use (eg, 1 g four times a day)1187.311.123.7
 Heavy alcohol consumption with gabapentin (when used for neuropathic pain)0000
 Heavy alcohol consumption with apomorphine0000
Endocrine system603.85.624.8
 Heavy alcohol consumption with insulin150.91.425.4
 Heavy alcohol consumption with metformin533.35.026.8
 Heavy alcohol consumption with sulphonylureas140.91.3117.3
 Heavy alcohol consumption with meglitinides (eg, nateglinide)0000
 Heavy alcohol consumption with thiazolidinediones (eg, pioglitazone)0000
Musculoskeletal and joint diseases714.46.730.6
 Heavy alcohol consumption with any non-steroidal anti-inflammatory drugs (including COX-2 inhibitors)633.95.929.9
 Heavy alcohol consumption combined with methotrexate or leflunomide70.40.725.0
Malignant disease and immunosuppression0000
 Any alcohol consumption with procarbazine0000
 Heavy alcohol consumption with interferon-alpha or interferon-beta0000
Infection493.14.675.4
 Heavy alcohol consumption with antimycobacterial medications such as isoniazid, pyrazinamide, ethionamide and rifampicin (alone or in combination)0000
 Any alcohol consumption with cycloserine0000
 Any alcohol consumption with metronidazole or tinidazole493.14.675.4
  • Any individual POSAMINO criteria with less than five individuals are not reported in this table to ensure anonymity of respondents.

  • *The denominator for medication users varied across drug classes; cardiovascular system (n=1066); respiratory system (n=19); central nervous system (n=791); endocrine system (n=241); musculoskeletal and joint diseases (n=231); malignant disease and immunosuppression (n=0); infection (n=65).

  • POSAMINO, POtentially Serious Alcohol-Medication INteractions in Older adults.