Table 2

Titration and initial maintenance dose

Arm A
Age >12 years
Lamotrigine Levetiracetam Zonisamide
25 mg once per day for 2 weeks250 mg once per day for 2 weeks50 mg once per day 2 weeks
25 mg two times per day for 2 weeks250 mg two times per day for 2 weeks50 mg two times per day for 2 weeks
50 mg two times per day for 2 weeks250 mg morning and 500 mg night
for 2 weeks
50 mg am and 100 mg pm for 2 weeks
50 mg morning and 100 mg at night—initial target maintenance dose 500 mg two times per day—initial target maintenance dose 100 mg am 100 mg pm—initial target maintenance dose
Children aged 5–12 years
Lamotrigine Levetiracetam Zonisamide
0.5 mg/kg/ day as once a day dose for 2 weeks10 mg/kg/day as two times daily regimen for 2 weeks0.5–1 mg/kg/day as once or two times daily regimen (depending on the child's weight) for 2 weeks
0.5 mg/kg/day as two times daily regimen for 2 weeks20 mg/kg/day as two times daily regimen for 2 weeks1–1.5 (maximum) mg/kg/day as two times daily regimen for 2 weeks
0.5 mg/kg am and 1.0 mg/kg pm for 2 weeks30 mg/kg/day as two times daily regimen for 2 weeks2–2.5 (maximum) mg/kg/day as two times daily regimen for 2 weeks
1.0 mg/kg am and 1.0 mg/kg pm for 2 weeks40 mg/kg/day as two times daily regimen—initial target maintenance dose 3–4 mg/kg/day as two times daily regimen for 2 weeks
1.5 mg/kg am and 1.5 mg/kg pm—initial target maintenance dose 5 mg/kg/day as two times daily regimen—initial target maintenance dose.
Arm B
Age >12 years
Valproate Levetiracetam
500 mg once per day for 2 weeks250 mg once per day for 2 weeks
500 mg two times per day—initial target maintenance dose 250 mg two times per day for 2 weeks
250 mg morning and 500 mg night for 2 weeks
500 mg two times per day—initial target maintenance dose
Children aged 5–12 years
Valproate Levetiracetam
10 mg/kg/day as two times daily regimen for 2 weeks10 mg/kg/day as two times daily regimen for 2 weeks
15 mg/kg/day as two times daily regimen for 2 weeks20 mg/kg/day as two times daily regimen for 2 weeks
25 mg/kg/day as two times daily regimen—initial target maintenance dose 30 mg/kg/day as two times daily regimen for 2 weeks
40 mg/kg/day as two times daily regimen—initial target maintenance dose