ICD-10 code | 1999 Age-adjusted mortality rate per million | 2017 Age-adjusted mortality rate per million | Per cent change, 95% CI | P value | Per cent change per year | |
All-cause mortality | 8756.34 | 7319.17 | −16.4%, 16.3% to 16.6% | <0.001 | <0.001 | |
Stroke | I60–I69 | 616.03 | 375.90 | −39.0%, 38.5% to 39.4% | <0.001 | <0.001 |
All neurological disorders | G00–G98 | 309.21 | 558.97 | +80.8%, 79.4% to 82.1% | <0.001 | <0.001 |
Degenerative disorders of the CNS | G30–G31 | 168.90 | 367.58 | +117.6%, 115.5% to 119.7% | <0.001 | <0.046 |
Epilepsy: multiple cause of death | G40.0–G40.9 | 5.83 | 11.59 | +98.8%, 88.2% to 110.0% | <0.001 | <0.001 |
Rates are expressed as number per million. Mortality per cent changes per year were evaluated using the weighted linear regression model; approximate formulas by Smith et al.10
CNS, central nervous system; ICD, International Classification of Diseases.