Table 1

Research questions

What clinical prediction models exist to diagnose neonatal sepsis?
What modelling methods are used to derive these models?
What predictors are used in these models?
  •  Symptoms and signs

  •  Risk factors

  •  Laboratory tests

What is the evidence underlying the use of these models?
  •  Type of studies

  •  Diagnostic accuracy

  •  Success of implementation

  •  Clinical efficacy

How do these models differ between HICs and LMICs?
  •  Number that exists

  •  Predictors used

  •  Evidence supporting use

What questions remain unanswered regarding clinical prediction models to diagnose neonatal sepsis?
  • HIC, high-income countries; LMIC, low-income and middle-income country.