At least one altered sign (glossitis and/or altered vibration sensitivity and/or altered position sensitivity)
Visit	N	n (%)	N	n (%)	P value	Proportion difference (95% CI)
Baseline	140	16 (11.4)	143	21 (14.7)	0.416	−3.3 (−11.1 to 4.6)
Week 8	135	15 (11.1)	130	13 (10.0)	0.769	1.1 (−6.3 to 8.5)
Week 26	131	14 (10.7)	122	12 (9.8)	0.824	0.9 (−6.6 to 8.3)
Week 52	122	14 (12.5)	117	9 (7.7)	0.226	3.8 (−3.7 to 11.2)