Table 1

Included studies

RefAuthorYearCountryTitleNMethodsPeriodMean follow-up
4Murphy et al42017AustraliaExtravasation injury in a paediatric population43Retrospective series
10Falcone et al101989USANonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement15Retrospective series6 months
11Ghanem et al112015UKChildhood extravasation injuries: improved outcome following the introduction of hospital-wide guidelines48Prospective series1 year
12Kostogloudis et al122015GreeceSevere extravasation injuries in neonates: a report of 34 cases34Retrospective series2 years15 months
13Sung and Lee132016KoreaNonoperative management of extravasation injuries associated with neonatal parenteral nutrition using multiple punctures and a hydrocolloid dressing12Retrospective series4 years10 months
14Odom et al142018USAPeripheral infiltration and extravasation injury methodology: a retrospective study147Retrospective series
15Compaña et al152017SpainLesions associated with calcium gluconate extravasation4Retrospective series2 months
16Harris et al162001UKLimiting the damage of iatrogenic extravasation injury in neonates56Prospective series3 years
17Andrés et al172006SpainTreatment protocol for extravasation lesions15Retrospective series6 years
18
19
Linder et al18 19 1983,
 1985
USAManagement of extensive doxorubicin hydrochloride extravasation injuries
Prevention of extravasation injuries secondary to doxorubicin
18Retrospective series3 months
20Upton et al201979USAMajor intravenous extravasation injuries7Retrospective series10 years
21Casanova et al212001FranceEmergency treatment of accidental infusion leakage in the newborn: report of 14 cases14Retrospective series
22von Heimburg and Pallua221998GermanyEarly and late treatment of iatrogenic injection damage5Retrospective series
23Weiss et al231975IsraelLocalized necrosis of scalp in neonates due to calcium gluconate infusions: a cautionary note4Retrospective series
24Hanrahan242013USAHyaluronidase for treatment of intravenous extravasations: implementation of an evidence-based guideline in a pediatric population113Before-and-after study4 years
25Boyar and Galiczewski252018USAEfficacy of dehydrated human amniotic membrane allograft for the treatment of severe extravasation injuries in preterm neonates4Retrospective series1–2 months
26Yan et al262017ChinaIncidence, risk factors and treatment outcomes of drug extravasation in pediatric patients in China18Retrospective series6 months1–5 months
27Myers et al272018USAManaging intravenous infiltration injuries in the neonatal intensive care unit28Retrospective series7 years
28Cochran et al282002USATreatment of iodinated contrast material extravasation with hyaluronidase8Retrospective series7 years
29Cho et al292007KoreaSuccessful combined treatment with total parenteral nutrition fluid extravasation injuries in preterm infants5Retrospective series4 months
30Onesti et al302012ItalyThe use of hyalomatrix PA in the treatment of extravasation affecting premature neonates26Retrospective series6 years14 months
31Firat et al312013TurkeyManagement of extravasation injuries: a retrospective study13Retrospective series2 years
32Ching et al322014UKPaediatric extravasation injuries: a review of 69 consecutive patients69Retrospective series1 year3 days
33Sivrioglu and Irkoren332014TurkeyVersajet hydrosurgery system in the debridement of skin necrosis after calcium gluconate extravasation: report of 9 infantile cases9Cohort study1 year
34Yan et al342014ChinaTreatment of cutaneous injuries of neonates induced by drug extravasation with hyaluronidase and hirudoid13Retrospective series2 years3 months