Table 2

Investigation schedule of the APPROACH cohort study

ScreeningBL6 months12 months24 months
Medical historyXXXXX
General physical examination
 HeightX
 WeightXXXXX
 Waist circumferenceXXXX
 Blood pressure and pulse rateXXXX
Joint examination
 ACR criteria for knee OAX
 KneeXXXX
 HandXXXX
 HipXXXX
Radiography
 Index kneeXXXX
 Contralateral kneeXX
 HandsXX
CT-scan
 Index kneeXX
 Whole Body Low Dose CTXX
MRI-scan of index knee
 Thickness and volume of cartilage, denuded bone areaXXXX
 MOAKS assessmentXXXX
 T2-mappingXX
Hand scanXX
Motion analysisXXX
Performance-based tests
 40-metre self-paced walk testXXX
 30 s chair stand-up testXXX
Questionnaires
 KOOS (pain, stiffness and function)X
 KOOSXXXX
 HOOSXX
 ICOAP index kneeXXXX
 ICOAP hipXX
 FIHOAXX
 Pain NRS index kneeXXXXX
 Pain NRS other jointsXXXXX
 PainDETECTXXXX
 SF-36XXXX
 One month pain diaryXXXX
Biological samples
 SerumXXXX
 PlasmaX
 DNA/RNAXX
 UrineXXXX
  • ACR, American College of Rheumatology; APPROACH, Applied Public-Private Research enabling OsteoArthritis Clinical Headway; BL, baseline; FIHOA, Functional Index for Hand Osteoarthritis; HOOS, Hip disability and Osteoarthritis Outcome Score; ICOAP, Intermittent and Constant OsteoArthritis Pain; KOOS, Knee Injury and Osteoarthritis Outcome Score; MOAKS, MRI osteoarthritis knee score; NRS, Numeric Rating Scale; OA, osteoarthritis; SF-36, Short Form 36.