| 1. Life-limiting or life-threatening condition | Children from the source population who have prevalent diagnosis event records for life-limiting conditions, either in the Clinical or Referral files in CPRD GOLD based on the Read codes detailed in online supplementary material, or in HES APC based on the ICD-10 codes in online supplementary material. Children have the above events before the end of the study period (31 December 2017). Children have the above events within their UTS follow-up period. Children are aged 18 years or less on the diagnosis event date.
| None |
| 2. A chronic condition that is not life-limiting | One matching control will be provided for each case in Group 1. The controls will comprise patients from the source population who fulfil the following criteria:Children from the source population who have diagnosis event records for other chronic conditions in the Clinical or Referral files in CPRD GOLD based on the Read codes detailed in online supplementary material, or in HES APC based on the ICD-10 codes in online supplementary material. Children have the above events before the end of the study period (31 December 2017). Children have the above events within their UTS follow-up period. Children are aged 18 years or less on the diagnosis date.
| Children who have deregistered from the CPRD on or before 01 April 2007. Children who are siblings of children in the case population (Group 1), based on having a link to the same mother in the mother–baby link. Children with a diagnosis on or before 31 December 2017 of life-limiting conditions, either in the Clinical or Referral files in CPRD GOLD based on the Read codes detailed in online supplementary appendix 1, or in HES APC based on the ICD-10 codes in online supplementry appendix 2.
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| 3. No long-term conditions | Up to two matching controls will be provided for each case in Group 1. The controls will comprise of patients from the source population who fulfil the following criteria: | Children with a diagnosis of life-limiting conditions on or before 31 December 2017, either in the Clinical or Referral files in CPRD GOLD based on the Read codes detailed in online supplementary appendix 1, or in HES APC based on the ICD-10 codes in online supplementary appendix 2, will be excluded.
Children with a diagnosis of other chronic conditions on or before 31 December 2017, in the Clinical or Referral files in CPRD GOLD based on the Read codes detailed in online supplementary appendix 3, or in HES APC based on the ICD-10 codes in online supplementary appendix 4, will be excluded. Children who have deregistered from the CPRD on or before 01 April 2007. Children who are siblings of children in the case population (Group 1), based on having a link to the same mother in the mother–baby link.
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