PICOS strategy46 | Inclusion criteria | Exclusion criteria |
P—Population | Studies of children, defined as being aged under 18 years, diagnosed with conditions associated with ICH. | (i) Studies of adults aged 18 years old or over; (ii) Studies not pertaining to the diagnosis of ICH. |
I— Intervention | Studies employing OCT to detect ICH. | Any studies that do not include OCT. |
C— Comparator | Absence of a comparator will not lead to exclusion of studies, as it may be unethical to deprive one arm of the study of OCT when it may lead to a better clinical outcome in such a dangerous situation of ICH. | N/A |
O— Outcome | Sensitivity and specificity of any OCT measure(s), ±surrogate measure(s), for ICH. | Studies that do not report OCT measures. |
S— Study design | All level IV evidence and above, that is, systematic reviews, randomised controlled trials, cohort studies, case-control studies and case series, as defined by the Oxford Centre for Evidence-based Medicine.51 | Level 5 evidence, that is, expert opinion without critical appraisal. |
ICP, intracranial pressure; N/A, Not applicable; OCT, optical coherence tomography; PICOS, Population Intervention Comparison Outcome and Study design.