Table 4

Cox proportional hazards survival analysis (model 6) for 3-year overall survival in women aged ≥50 years with ER-positive early invasive breast cancer in England between 2014 and 2017

Total number of women% women alive at 3 yearsAdjusted OR95% CIP value
Age at diagnosis (years)67 925941.061.05 to 1.06<0.001
Invasive grade
 G113 352961<0.001
 G240 999941.050.96 to 1.16
 G313 574911.641.47 to 1.83
Tumour size (T stage)
 1–20 mm (T0–1)41 225951<0.001
 21–50 mm (T2)23 974901.311.22 to 1.41
 51+mm (T3)2 726891.691.48 to 1.93
Nodal metastasis (N-stage)
 N049 837941<0.001
 N115 594931.391.29 to 1.50
 N22 494892.161.88 to 2.49
HER2 status
 Positive6 271921<0.001
 Negative56 564940.810.73 to 0.90
 Borderline5 090920.820.71 to 0.95
Deprivation status
 1 (most deprived)10 065911<0.001
 212 131930.860.78 to 0.95
 314 137940.740.67 to 0.82
 415 998940.770.70 to 0.85
 5 (least deprived)15 594950.670.61 to 0.75
Charlson Comorbidity Index
 058 488961<0.001
 16 259871.251.11 to 1.40
 22 057771.411.22 to 1.62
 3+1 121591.861.59 to 2.18
Secondary care administrative records frailty index index
 Fit53 800961<0.001
 Mild frailty7 501921.221.09 to 1.36
 Moderate frailty4 498821.441.27 to 1.64
 Severe frailty2 126611.631.41 to 1.89
Surgery
 No6 112641<0.001
 Yes61 813960.210.20 to 0.23
  • *P value from z-test for continuous variables and Wald test for categorical variables.