Table 1

Baseline tumour characteristics of women diagnosed with ER-positive early invasive breast cancer between 2014 and 2017 in England and Wales by age group at diagnosis

England (internal validation)Wales (external validation)
Age group at diagnosis (n (%))TotalAge group at diagnosis (n (%))Total
50–69 years70–79 years≥80 years50–69 years70–79 years≥80 years
Total number of women44 62414 8628 43967 9252 8129844344 230
Invasive grade
 G19 539 (21)2 490 (17)1 323 (16)13 352770 (27)208 (21)69 (16)1 047
 G226 184 (59)9 304 (63)5 511 (65)40 9991 585 (56)602 (61)290 (67)2 477
 G38 901 (20)3 068 (21)1 605 (19)13 574457 (16)174 (18)75 (17)706
Tumour size (T stage)
 1–20 mm (T0–1)29 426 (66)8 314 (56)3 485 (41)41 2251 921 (68)550 (56)163 (38)2 634
 21–50 mm (T2)13 505 (30)5 947 (40)4 522 (54)23 974779 (28)407 (41)242 (56)1 428
 51+mm (T3)1 693 (4)601 (4)432 (5)2 726112 (4)27 (3)29 (7)168
Nodal status (N stage)
 N032 573 (73)10 850 (73)6 414 (76)49 8372 306 (82)813 (83)377 (87)3 496
 N110 494 (24)3 375 (23)1 725 (20)15 594403 (14)143 (15)50 (12)596
 N21 557 (3)637 (4)300 (4)2 494103 (4)28 (3)7 (2)138
HER2 status
 Positive4 380 (10)1 215 (8)676 (8)6271300 (11)90 (9)41 (3)431
 Negative37 028 (83)12 543 (84)6 993 (83)56 5642 512 (89)894 (91)393 (97)3 799
 Borderline3 216 (7)1 104 (7)770 (9)5 090
IMD status
 1 – most deprived6 812 (15)2 014 (14)1 239 (15)10 065451 (16)154 (16)59 (14)664
 28 042 (18)2 548 (17)1 541 (18)12 131524 (19)175 (18)89 (21)788
 39 221 (21)3 107 (21)1 809 (21)14 137599 (21)191 (19)105 (24)895
 410 412 (23)3 618 (24)1 968 (23)15 998573 (20)211 (21)77 (18)861
 5 – least deprived10 137 (23)3 575 (24)1 882 (22)15 594665 (24)253 (26)104 (24)1 022
Charlson Comorbidity Index
 040 751 (91)12 133 (82)5 604 (66)58 4882 623 (93)864 (88)296 (68)3 783
 12 955 (7)1 796 (12)1 508 (18)6 259150 (5)83 (8)81 (19)314
 2697 (2)625 (4)735 (9)205733 (1)25 (3)34 (8)92
 3+221 (0)308 (2)592 (7)11216 (0)12 (1)23 (5)41
SCARF index*
 Fit38 682 (87)10 713 (72)4 405 (52)53 8002 507 (89)757 (77)232 (53)
 Mild frailty3 897 (9)2 224 (15)1 380 (16)7 501216 (8)131 (13)89 (21)
 Moderate frailty1 670 (4)1 367 (9)1461 (17)449873 (3)73 (7)59 (14)
 Severe frailty375 (1)558 (4)1193 (14)212616 (1)23 (2)54 (12)
  • *Classification of the SCARF index: fit=0–1 deficit (index: 0–0.05), mild frailty=2–3 deficits (index: 0.06–0.11), moderate frailty=4–5 deficits (index: 0.12–0.18) and severe frailty=6 or more deficits (index: ≥0.19).

  • ER, Oestrogen receptor; HER2, human epidermal growth factor receptor 2; IMD, Index for multiple deprivation; SCARF, secondary care administrative records frailty.