Table 2

Association of exposures with wheeze in past 12 months

Total number=1106No (%, SD)OR of wheeze (95% CI)
Prior exposures
Any wheeze in first year of life514 (46)1.89 (1.65 to 2.16)
Family history of asthma614 (56)1.66 (1.40 to 1.97)
Attendance at nursery159 (14)0.84 (0.57 to 1.24)
Paracetamol in first year of life256 (23)1.64 (1.14 to 2.35)
Mean birth weight, N, kg (SD) n=11043.31 (0.51)0.87 (0.75 to 1.01)
Mean birth height, cm (SD)50.2 (2.4)0.95 (0.89 to 1.00)
Breast feeding ≥4 months608 (55)0.83 (0.66 to 1.03)
Age=1 year
Mean log IgE, n=8853.38 (1.47)1.06 (0.88 to 1.27)
Mean log eosinophils, n=856−2.11 (1.05)0.93 (0.77 to 1.13)
Age=2 years
Helicobacter stool +ve, n=106740 (4)0.57 (0.40 to 0.82)
Age=3 years
Mean log CRP, SD, n=986−2.07 (2.70)1.01 (0.95 to 1.07)
Log dengue IgG, n=865−0.44 (2.00)0.99 (0.96 to 1.02)
Helicobacter stool +ve, n=95158 (6)1.01 (0.64 to 1.60)
Mean log eosinophils, n=1039−1.77 (1.23)0.91 (0.86 to 0.96)
Toxoplasmosis serology +ve, n=966565 (58)1.15 (0.82 to 1.64)
Mean log IgE, n=9863.70 (1.53)1.14 (0.98 to 1.31)
Medical diagnosis of dengue infection93 (8)1.40 (0.91 to 2.14)
Current exposures
Male sex575 (52)1.35 (1.00 to 1.82)
Age (months), (range)74 (63 to 83)0.97 (0.96 to 0.99)
Mean current weight, kg, n=106223.3 (11 to 51)1.01 (0.97 to 1.06)
Current height, cm, n=1057119 (7)1.00 (0.97 to 1.03)
Mean arm circumference, cm, n=106218.3 (2.4)1.02 (0.95 to 1.08)
Number of current smokers in house
0546 (49)0
1322 (29)1.61 (1.22 to 2.12)
≥2238 (22)2.08 (1.71 to 2.54)
Municipality of residencePTREND <0.001
Arroyo Naranjo455 (41)0
Cerro139 (13)1.72 (1.61 to 1.84)
Habana del Este307 (28)0.86 (0.84 to 0.88)
La Lisa205 (19)1.24 (1.21 to 1.27)
P=0.04
Current infection and blood assays
Helicobacter stool antigen +ve, n=75611 (1)1.45 (0.63 to 3.33)
Toxoplasmosis +ve, n=759487 (64)0.97 (0.70 to 1.34)
Mean log dengue IgG serology, n=7581.67 (1.53)0.95 (0.90 to 1.01)
Log CRP, n=757−0.83 (1.41)0.99 (0.86 to 1.15)
Mean log eosinophils, n=868−1.62 (1.45)1.02 (0.90 to 1.15)
Mean log IgE, n=7594.51 (0.97)1.27 (1.15 to 1.41)
Toxocariasis +ve, n=67364 (9)0.96 (0.70 to 1.33)
Any atopy* (n=857)52 (6)0.81 (0.43 to 1.53)
  • Results in bold font have a probability of <0.05.

  • CRP, C-reactive protein.