Differences between the registered protocol and manuscript in the group of trials that did not have discrepancies within the registered protocol itself (trials: N=88)
| Differences between protocol and published manuscript | n (%) |
| Different individuals described as blinded between registeredprotocol and manuscript | 30 (34) |
| Registered protocol reported who was blinded; manuscript did not | 10 (11) |
| Registered protocol: triple-blind; manuscript: double-blind | 9 (10) |
| Registered protocol reported who was blinded; manuscript only that it was double-blind | 9 (10) |
| Registered protocol: open label, manuscript: blinding of one or more groups of individuals | 8 (9) |
| Registered protocol has a description of blinding; manuscript no description of blinding | 7 (8) |
| Registered protocol: quadruple-blind; manuscript: double-blind | 6 (7) |
| Registered protocol double-blind, manuscript single-blind | 2 (2) |
| Study described as observational on ClinicalTrials.gov | 2 (2) |
| Registered protocol: quadruple-blind; manuscript: triple-blind | 2 (2) |
| Registered protocol: no information about blinding; manuscript reported information about blinding | 1 (1) |
| Registered protocol: open label; manuscript only reported that participants were not blinded | 1 (1) |
| Registered protocol: single-blind; manuscript: double-blind | 1 (1) |