Table 3

Validation of the regular expression-based classification algorithm

Diagnosis tiers*Sensitivity (%, 95% CI)Specificity (%, 95% CI)PPV (%, 95% CI)NPV (%, 95% CI)
Tier 1A98.0 (96.0 to 99.2)100.0 (100.0 to 100.0)100.0 (98.9 to 100.0)99.9 (99.9 to 100.0)
Tier 1B97.6 (87.4 to 99.9)100.0 (99.9 to 100.0)97.6 (87.4 to 99.9)100.0 (99.9 to 100.0)
Tier 2A98.1 (97.1 to 98.8)100.0 (99.9 to 100.0)99.7 (99.2 to 99.9)99.8 (99.6 to 99.9)
Tier 2B98.4 (91.6 to 100.0)100.0 (99.9 to 100.0)94.0 (85.4 to 98.3)100.0 (99.9 to 100.0)
Tier 198.2 (96.4 to 99.3)100.0 (100.0 to 100.0)100.0 (99.1 to 100.0)99.9 (99.8 to 100.0)
Tier 298.4 (97.6 to 99.1)100.0 (99.9 to 100.0)99.7 (99.2 to 99.9)99.8 (99.7 to 99.9)
Tier 3100.0 (100.0 to 100.0)98.6 (97.9 to 99.1)99.7 (99.6 to 99.8)100.0 (99.8 to 100.0)
  • *Tier 1A: tier 1 diagnoses without uncertainty. Tier 1B: tier 1 diagnoses with uncertainty. Tier 2A: tier 2 diagnoses without uncertainty. Tier 2B: tier 2 diagnoses with uncertainty.

  • NPV, negative predictive value; PPV, positive predictive value.