Table 2

Felodipine and dehydrofelodipine pharmacokinetics

Healthy controls
Water (68)
Patients with coeliac disease
Group A (15)
Patients with coeliac disease
Group B+C (16)
Patients with coeliac disease
Group D (16)
Healthy controls
Grapefruit (68)
Felodipine
 AUC08
 (ng.h/mL)
11.9±0.914.4±2.117.2±2.825.7±5.0*26.8±0.9†
 AUC0
 (ng.h/mL)
16.3±1.420.5±4.527.9±4.536.9±5.6*36.8±3.5†
 Cmax
 (ng/mL)
2.9±0.23.5±0.54.0±0.66.4±1.1‡7.7±0.2†
 tmax
 (hours)
3.4±0.23.3±0.43.2±0.33.4±0.43.0±0.1
 t½
 (hours)
4.5±0.52.6±0.73.6±0.74.5±1.04.7±0.8
Dehydrofelodipine
 AUC08
 (ng.h/mL)
19.9±1.317.4±2.125.9±3.928.0±3.8*27.8±1.6†
 AUC0–∞
 (ng.h/mL)
25.0±1.721.3±2.533.0±6.034.2±4.139.4±3.1†
 Cmax
 (ng/mL)
5.4±0.34.4±0.56.5±0.87.4±1.2‡8.4±0.5†
 tmax
 (hours)
2.9±0.12.5±0.32.8±0.32.9±0.33.0±0.1
 t½
 (hours)
3.9±0.52.2±0.32.7±0.45.6±1.3‡4.8±0.7
Dehydrofelodipine/felodipine ratio
 AUC0–82.0±0.11.8±0.51.8±0.31.5±0.21.3±0.1†
  • Data are presented as mean±SEM.

  • Healthy controls—water versus grapefruit.

  • *p<0.05.

  • †p = 0.0001 Healthy controls—water versus grapefruit.

  • ‡p<0.02.

  • AUC0–∞, area under concentration time curve from 0 to infinity; AUC0–8, area under concentration time curve from 0 to 8 hours; Cmax, peak drug concentration; t1⁄2, apparent elimination half-life.