Table 2

Characteristics of studies for probiotics for infantile colic

AuthorsParticipants/n/age/genderTreatment and timing of interventionNumber of studies: type of studies included in reviewMethod of data synthesis (narrative/meta-analysis)
Anabrees et al52Breastfed or partly breastfed infants/n=209/<4 months/gender not reportedL.reuteri (strains—American Type Culture Collection Strain 55730 and DSM 17938)
21 days and 28 days
3: 1× Open prospective randomised study, 2× double-blind RCTsMeta-analysis
Batchelor et al53Infants/n=924/newborns <3 months (where reported)/gender not reportedL.reuteri. 21 days and 90 days (where reported)5: 3× RCTs, 1× observational prospective and 1× meta-analysisNarrative
Cruchet et al33Infants/n=not reported/age not reported/gender not reportedL.reuteri, B.lactis and Str. thermophiles
Not reported
9: 1× SR, 8× RCTsNarrative
Dryl and Szajewska54Infants/n=471/<6 months/gender not reportedL.reuteri. 21–30 days7 RCTsMeta-analysis
Mugambi et al25Healthy infantsMixed: synbiotics, probiotics, prebiotics (various strains used). Not reported25 RCTsMeta-analysis
Ong et al17Infants/n=1886/<1 monthL.reuteri DSM, multistrain probiotics, L. rhamnosus, L. paracasei and B. animalis
4/52 before delivery to 6 months
6 RCTsMeta-analysis
Schreck Bird et al55Infants/n=444/31–52 daysL.reuteri DSM 17938 (108 CFU)
21 and 28 days
5 RCTsNarrative
Skórka et al26Infants/4 weeks to 36 monthsVarious probiotic strains included. 4 weeks to 12 months20 RCTsNarrative
Sung et al56Infants/n=1825/<3 monthsVarious strains probiotics. 2 weeks to 6 months12 RCTsMeta-analysis
Sung et al57Infants/n=345/birth to 23 monthsL.reuteri DSM 17938
21 days
4 RCTsMeta-analysis
  • CFU, colony-forming unit; RCT, randomised controlled trial; SR, systematic review.