Table 6

Summary of meta-analyses of treatments for infant colic measured by crying time

AuthorTime point24 hours crying timeEffectLevel of evidenceAMSTAR
Probiotics*
Ong et al1730–90 days−32.57 min
(95% CI −55.6 to −9.54)
FavourableLow7
Dryl and Szajewska5421 days and 28 days−49 min
(95% CI −66 to −33) for L.reuteri only
FavourableHigh5.5
Sung et al5721 days−25.4 min (95% CI −47.3 to −3.5)FavourableHigh6.5
Gutiérrez-Castrellón et al307–28 daysWMD −51.3 min (95% CI −30.5 to −72.2 min), p=0.0001FavourableHigh7
Schreck Bird et al5521 days
28 days
2.3 times more likely to have a ≥50% reduction (p=0.01)FavourableHigh6
Harb et al3121 and 30 days−55.8 min
(95% CI −64.4 to −47.3)
FavourableHigh8
Xu et al5814 days
21 days
−42.89 min
(95% CI –60.50 to –25.29; p=0.000)
−45.83 min
(95% CI –59.45 to –32.21; p=0.000)
FavourableHigh7
Urbańska and Szajewska5921 days
1 month
−43 min/day
(95% CI −68 to −19)
FavourableHigh4.5
Sung et al5621 days−65 min
(95% CI −86 to −44)
InconclusiveLow8
Anabrees et al5221 and 28 days−56.03 min (95% CI −59.92 to −52.15), RR of 0.06 (95% CI 0.01 to 0.25) NNT 2FavourableModerate8
Simethicone
Gutiérrez-Castrellón et al307–28 daysWMD −30.0 min (95% CI −20.8 to −39.0 min), p=0.001 for drugs including simethiconeInconclusiveModerate7
Biagioli et al197 days−0.13 hours
(95% CI −1.40 to 1.14)
Not favourableLow8
Manual therapy
Carnes et al431–4 weeks−1.27 hours
(95% CI −2.19 to −0.36)
FavourableModerate8
Gutiérrez-Castrellón et al307–28 daysWMD −37.4 min (95% CI −21.5 to −67.0 min), p=0.001InconclusiveModerate7
Dobson et al168 days to 4 weeks−1.2 hours
(95% CI −1.89 to 0.51)
FavourableLow8
Driehuis et al428–10 days−0.33 hours per day (95% CI −0.012 to 0.59)FavourableLow8
  • *Predominantly breastfed infants.

  • NNT, number needed to treat; RR, risk ratio; WMD, weighted mean difference.