Table 8

Summary of narrative analyses of treatments for infant colic measured by crying time

Author	vs control	Time point	Effect	Level of evidence	AMSTAR
Probiotics
Batchelor et al53	Not reported	21 days and 90 days	Not favourable	Not reported	2.5
Cruchet et al33	Simethicone	7, 14 and 21 days	Favourable	High prevention, Moderate treatment	4.5
Lucassen2	Placebo	21 days	Inconclusive	Very Low	2
Perry et al32	Placebo and Simethicone	14 and 28 days	Inconclusive	Low	8
Simethicone
Harb et al31	Placebo, mint and probiotics	17–21 days	Not favourable	Not reported	8
Hall et al34	Placebo	2–8 weeks	Not favourable	Low	4
Manual therapy
Alcantara et al38	Dimethicone, no treatment, occipitosacral decompression	14 days and 4 weeks where reported	Inconclusive	Not reported	5
Ernst41	Not reported	8 days to 2 weeks	Not favourable	Low	4.5
Lucassen2	No treatment	10–14 days	Unfavourable	Low	2
Perry et al32	Dimethicone or no treatment	8 days to 4 weeks	Inconclusive	Low	8
Clar et al39	Not reported	Not reported	Inconclusive (favourable)	Low to moderate	8
Gleberzon et al36	Not reported	<4 weeks	Favourable	Low	6
Parnell Prevost et al40	Not reported	Not reported	Inconclusive	Moderate to high	7
Posadzki et al37	Not reported	4 weeks	Favourable (1 RCT only)	Low	7
Proton pump inhibitors
Gieruszczak-Białek et al35	Placebo	2–4 weeks	Not favourable	Not reported	3.5