Table 1

Study interventions

Groups	Products	Ingredients	Dosage	Instructions
Active	Supplement combination	(i) Combined supplement: each capsule contains 83 mg of BSE, 33 mg of PBE and 500 mg of MSM.	2 Capsules in the morning, 1 capsule in the evening.	4 Capsules in the morning, 3 capsules in the evening, taken orally with water after meals.
Active	Supplement combination	(ii) Curcumin: each capsule contains 42 mg of curcumin.	2 Capsules in the morning, 2 capsules in the evening.
Placebo	Placebo combination	(i) Placebo-combined supplement: microcrystalline cellulose USP.	2 Capsules in the morning, 1 capsule in the evening.	4 Capsules in the morning, 3 capsules in the evening, taken orally with water after meals.
Placebo	Placebo combination	(ii) Placebo curcumin: sunflower seed oil.	2 Capsules in the morning, 2 capsules in the evening.

BSE, Boswellia serrata extract; MSM, methylsulfonylmethane; PBE, pine bark extract; USP, United States Pharmacopoeia.