Table 2

Spirit diagram of enrolment, interventions and assessments for the RADIANT study

Time points	Enrolment	Baseline	Day 1	Postscheduling day 1
Time points	−t₂	−t₁	0	w₁	w₂	w₃	w₄	w₅	w₆	w₇	w₈	w₉	w₁₀	w₁₁	w₁₂
Enrolment
Initial online screening	X
Hand X-ray referral*	X
Hand photo screening	X
Radiographic screening	X
Eligibility assessment	X
Informed consent	X
Medication washout*	X
Treatment allocation		X
Interventions
Active
Placebo
Assessments
Primary outcome
VAS pain		X													X
Secondary outcomes
AEs				X	X	X	X	X	X	X	X	X	X	X	X
VAS pain		X			X				X
FIHOA		X			X				X						X
PGA of disease activity		X			X				X						X
AQoL-4D		X			X				X						X
WPAI-GH		X													X
Other measures
Rescue medication use				X	X	X	X	X	X	X	X	X	X	X	X
Treatment adherence				X	X	X	X	X	X	X	X	X	X	X	X
Capsule count															X
Medication satisfaction															X
Global rating of change															X
MPsQ		X
Computer self-efficacy		X
Descriptive measures
Age, gender, BMI, symptom duration, X-ray severity, HOA phenotype, comorbidity, concomitant medication		X

*If applicable; −t₃: the period between completion of online screening to signed consent form; −t₂: washout period (if required); −t₁: the period between baseline survey and the phone call scheduling day 1; w1–w12: week 1–12.
AEs, adverse events; AQoL-4D, assessment of quality of life four dimension; BMI, body mass index; FIHOA, Functional Index for Hand Osteoarthritis; HOA, hand osteoarthritis; MPsQ, Multidimensional Personality Questionnaire; PGA, patient global assessment; VAS, Visual Analogue Scale; WPAI-GH, Work Productivity and Activity Impairment Questionnaire General Health.