Percentage change in cerebral oximetry (%ΔrSO2) from baseline
| Time from start of surgery (min) | 15 | 30 | 45 | 60 | 75 | 90 | 105 | 120 |
| Left | ||||||||
| TMH | 0.8 (12.9) {15} | 5.8 (12.3) {15} | 9.0 (15.9) {15} | 7.0 (14.6) {15} | 8.5 (15.4) {14} | 7.3 (14.7) {13} | 7.7 (17.4) {13} | 8.1 (14.8) {13} |
| TN | 4.7 (10.5) {18} | 3.2 (15.4) {18} | −1.9 (14.1) {17} | −5.6 (12.7) {17} | −5.3 (15.2) {17} | −5.5 (15.8) {17} | −6.0 (15.2) {17} | −3.6 (15.8) {14} |
| Right | ||||||||
| TMH | 6.0 (12.9) {17} | 9.8 (13.2) {17} | 10.4 (18.1) {17} | 11.1 (17.4) {17} | 13.0 (16.4) {16} | 15.6 (17.3) {15} | 14.4 (17.5) {14} | 14.1 (13.6) {14} |
| TN | 5.2 (12.6) {20} | 3.9 (11.7) {20} | −3.3 (13.2) {19} | −5.2 (12.1) {19} | −5.4 (12.3) {19} | −4.7 (14.1) {19} | −3.8 (13.7) {18} | −1.3 (13.9) {15} |
| Time from start of surgery (min) | 120 | 240 | 360 | 480 | 600 | 720 | Mean % difference from start to completion of surgery | 95% CI | P value (treatment) |
| Left | 19.0 | 9.2 to −28.8 | <0.001 | ||||||
| TMH | 8.1 (14.8) {13} | 6.8 (20.6) {7} | 6.4 (32.5) {4} | −8.6 (21.1) {3} | −6.1 (14.1) {3} | 6.9 {1} | |||
| TN | −3.6 (15.8) {14} | −10.4 (39.5) {5} | −43.4 (34.9) {2} | −27.8 {1} | |||||
| Right | 19.0 | 10.9 to 27.0 | <0.001 | ||||||
| TMH | 14.1 (13.6) {14} | 18.4 (23.5) {8} | 16.8 (36.8) {4} | 1.5 (14.9) {3} | 3.0 (8.7) {3} | 2.0 {1} | |||
| TN | −1.3 (13.9) {15} | −5.3 (32.6) {5} | −35.4 (26.9) {2} | −37.8 {1} |
Data reported as mean (SD) {sample size} and presented every 15 min for the first 2 hours and every 2 hours afterwards.
TMH, targeted mild hypercapnia; TN, targeted normocapnia.