Table 3A

Summary of studies and their associations

NoAuthor (year)Study designTypes of allergyPurposeSample size and group comparisonSubjects characteristicsAssociation with ABO blood groups
1 Falsarella et al 25
Country: Brazil
Year: 2011
Case controlAllergic rhinitisTo determine if ABO phenotypes are associated with allergic rhinitis.168 patients and 168 controlsAge: 18–85 years, patients matched by age and gender with controlsThe O phenotype was associated with susceptibility to allergic rhinitis for men but not for women
(p=0.016; OR= 1.735; 95% CI 1.127 to 2.673).
2 Hamad26
Country: Iraq
Year: 2016
Cross sectionalAllergic rhinitisTo determine the prevalence of ABO blood groups and to investigate their association with allergic rhinitis and relate this association with genetics.109Age: 18–60 years (female and male)Group O is the most common and has a high level of risk for developing allergic rhinitis
(p=0.049).
3 Topno et al 27
Country: India
Year: 2017
Case controlAllergic rhinitisTo study the correlation of ABO phenotypes in patients with allergic rhinitis.100 patients and 100 controlsOutpatient department Ear,Nose and Throat (ENT)
Age: 11–70 years, patients matched by age and gender with controls
The O blood group phenotype is associated with allergic rhinitis
(OR 3.63, p=0.006).
4 Kauffmann et al 19
Country: France Year: 1996
Cross sectionalAsthmaTo assess the role of all three systems—Lewis, secretor and ABO—in lung function, wheezing and asthma.228 malesAge: 34–50 years, coal minersNon-secretor subjects of blood group O have significantly lower lung function and higher prevalence of wheezing and asthma
(p<0.01).
5 Ronchetti et al 20
Country:
Italy
Year: 2001
Case controlAsthmaTo analyse the joint phenotype ABO/secretor in a cohort of asthmatic children in an attempt to confirm the association observed in adult subjects.165 children (109 males and 56 females)
362 newborn infants as controls
Outpatients of a paediatric pulmonary clinic or patients who were admitted to a ward of the same clinic for acute respiratory episodes.
Age: 1 month–15 years
O/non-secretor in asthmatic male children was higher than the controls
(p<0.025).
6 Chen et al 28
Country: Taiwan
Year: 2005
Case controlAsthmaTo analyse the histo-blood groups of ABO, Lewis and secretor in a cohort of asthmatic children in Taiwan.136 asthmatic children and 161 aged-matched controlsAge: 6–13 yearsBlood group O/secretors were associated with childhood asthma
(OR=2.7, 95% CI 1.126 to 6.033, p<0.02)
7 Saini and Yadav29
Country: India
Year: 2014
Case controlAsthmaTo investigate the association of ABO and Rh (D) allele frequency in patients with asthma.180 subjects (120 asthmatics and 60 controls)Patients matched by age, sex and socioeconomic status with controlsA possible association between blood group O and asthma prevalence was noted
(p<0.05).
8 Yaro et al 30
Country: Nigeria
Year: 2015
Case controlAsthmaTo explore the relationship of blood group type and susceptibility to asthma in Sokoto Metropolis, Nigeria.200 asthmatic patients and 100 adults
(control group)
Individuals attending the Pulmonary Unit of Usmanu Danfodiyo University Teaching Hospital, Specialist Hospital and Maryam Abacha Women and Children Hospital, all in Sokoto metropolis, NigeriaA possible association between blood group A and asthma susceptibility was noted
(p<0.05).
9 Gangopadhyay et al 18
Country: India
Year: 2006
Cross sectionalAtopic dermatitisTo evaluate the relationship between atopic dermatitis and the ABO blood group.30 patients with atopic dermatitisPatients attending the Dermatology Outpatient Department (OPD) of NRS Medical College, Kolkata, over a period of 1 year
Age: 6 month–65 years
Blood group O with atopic dermatitis among patients is less prevalent than among controls (p<0.05). Blood group B is the most prevalent in patients with atopic dermatitis, followed by blood group A.
10 Abid33
Country: Pakistan
Year: 2015
Cross sectionalAtopic dermatitisTo determine the prevalence of ABO blood groups and to investigate their association with dust, pollen and skin allergy.123 young adults (males and females)Age: 18–21 yearsBlood group B is most common and has a high risk level for developing allergies
(p=0.0007774).
11 Brachtel et al 34
Country: Germany
Year: 1979
Case controlAtopyTo assess the association of atopic disease with blood group with reference to a new population sample and to include polymorphic systems.239 patients
151 controls
Outpatients of the Dermatological Clinic of the University of MainzHigher susceptibility of individuals with blood groups A and B to atopic diseases such as rhinitis, bronchial asthma, dermatitis and many more.