Table 1

Coprimary/secondary endpoints and key performance indicators of HELP

Coprimary endpointSecondary endpointsHealth economic, technical and process key performance indicators

  • Hospital mortality.

  • Relapse/mortality within 90 days.

  • Cumulative vancomycin use.

  • Acute renal dysfunction (measured by creatinine)

  • Cumulative use of: linezolid, daptomycin, teicoplanin, fosfomycin, rifampicin, flucloxacillin and cefazolin.

  • Number of blood cultures.

  • Number of administered transoesophageal echocardiographies.

  • Costs due to infectious diseases specialist consultation.

  • Number of ID consultations per ward (total and per patient day).

  • Adherence to HELP-CDSS recommendations.

  • Number of HELP-CDSS queries.

  • Satisfaction with HELP-CDSS (by survey and interviews after the study).

  • CDSS, computerised clinical decision support system.