Table 1

Characteristics of the included studies

Author	Year of publication	No of sites	Population			Transfusion triggers		Mortality data	References
Author	Year of publication	No of sites	Clinical settings	Details	Number of participants	Restrictive	Liberal	Mortality data	References
Hebert et al	1999	25	Critical illness	Euvolemic critically ill patients	838	Hb 7	Hb 10	30-day mortality
								60-day mortality	10
								ICU mortality
								Hospital mortality
Holst et al	2014	32	Critical illness	Patients with septic shock	998	Hb 7	Hb 9	90-day mortality	22
Mazza et al	2015	Single	Critical illness	Patients with septic shock	46	Hb 7	Hb 9	Hospital mortality	23
Robertson et al	2014	2	Traumatic brain injury	Patients with closed head injuries	200	Hb 7	Hb 10	6-month mortality	25
Villanueva et al	2013	Single	Upper gastrointestinal bleeding	Patients with hematemesis, melena or both	889	Hb 7	Hb 9	45-day mortality	26
Walsh et al	2013	6	Critical illness	Older critically ill patients receiving mechanical ventilation	100	Hb 7	Hb 9	30-day mortality
								60-day mortality
								180-day mortality	27
								ICU mortality
Bergamin et al	2017	Single	Critical illness	Patients with cancer with septic shock	300	Hb 7	Hb 9	Hospital mortality 28-day mortality
								60-day mortality	29
								90-day mortality
Gobatto et al	2019	Single	Traumatic brain injury	Patients with moderate or severe traumatic brain injury	44	Hb 7	Hb 9	Hospital mortality ICU mortality	28

ICU, intensive care unit.