Sample characteristics and logistic regression of factors associated with CTOs
Total group (n=4489) | Controls (n=3659) | CTO (n=830) | Unadjusted models | Adjusted models | ||||||||
n | % | n | % | n | % | OR | CI | P value | OR | CI | P value | |
Sex | ||||||||||||
Male | 2453 | 54.6 | 1931 | 52.8 | 522 | 62.9 | Ref | – | – | – | – | – |
Female | 2036 | 45.4 | 1728 | 47.2 | 308 | 37.1 | 0.66 | 0.56 to 0.77 | <0.001 | 0.83 | 0.71 to 0.99 | 0.042 |
Age group | ||||||||||||
<25 | 683 | 15.4 | 577 | 15.8 | 106 | 13.4 | 0.69 | 0.54 to 0.89 | 0.005 | 0.76 | 0.57 to 1.01 | 0.063 |
25–34 | 1045 | 23.5 | 826 | 22.6 | 219 | 27.8 | Ref | – | – | – | – | – |
35–44 | 1027 | 23.1 | 825 | 22.6 | 202 | 25.6 | 0.92 | 0.75 to 1.14 | 0.466 | 0.91 | 0.72 to 1.15 | 0.415 |
45–55 | 880 | 19.8 | 700 | 19.1 | 180 | 22.8 | 0.97 | 0.78 to 1.21 | 0.786 | 0.94 | 0.74 to 1.20 | 0.642 |
>55 | 813 | 18.3 | 731 | 20.0 | 82 | 10.4 | 0.42 | 0.32 to 0.56 | <0.001 | 0.48 | 0.36 to 0.65 | <0.001 |
Ethnicity | ||||||||||||
White | 1728 | 38.5 | 1449 | 39.6 | 279 | 33.6 | Ref | – | – | – | – | – |
Black | 2192 | 48.9 | 1727 | 47.2 | 465 | 56.0 | 1.40 | 1.19 to 1.65 | <0.001 | 1.08 | 0.89 to 1.30 | 0.457 |
Other | 566 | 12.6 | 480 | 13.1 | 86 | 10.4 | 0.93 | 0.72 to 1.21 | 0.591 | 0.79 | 0.59 to 1.07 | 0.134 |
Primary diagnosis | ||||||||||||
Schizophrenia | 2092 | 47.1 | 1609 | 44.0 | 483 | 61.2 | Ref | – | – | – | – | – |
Other psychotic | 628 | 14.1 | 544 | 14.9 | 84 | 10.7 | 0.51 | 0.40 to 0.66 | <0.001 | 0.60 | 0.46 to 0.79 | <0.001 |
Bipolar and related | 630 | 14.2 | 554 | 15.2 | 76 | 9.6 | 0.46 | 0.35 to 0.59 | <0.001 | 0.59 | 0.44 to 0.78 | <0.001 |
Depressive disorders | 428 | 9.6 | 365 | 10.0 | 63 | 8.0 | 0.57 | 0.43 to 0.77 | <0.001 | 0.93 | 0.68 to 1.26 | 0.629 |
Other | 668 | 15.0 | 585 | 16.0 | 83 | 10.5 | 0.47 | 0.37 to 0.61 | <0.001 | 0.63 | 0.47 to 0.84 | 0.002 |
Forensic status | ||||||||||||
Secondary care | 3983 | 92.8 | 3318 | 95.6 | 665 | 81.1 | Ref | – | – | – | – | – |
Forensic patient | 308 | 7.2 | 153 | 4.4 | 155 | 18.9 | 5.05 | 3.98 to 6.42 | <0.001 | 4.41 | 3.40 to 5.72 | <0.001 |
Route of antipsychotic | ||||||||||||
Oral | 3162 | 72.2 | 2741 | 74.9 | 421 | 58.2 | Ref | – | – | – | – | – |
LAI | 1142 | 26.1 | 844 | 23.1 | 298 | 41.2 | 2.30 | 1.94 to 2.72 | <0.001 | 2.18 | 1.83 to 2.61 | <0.001 |
None | 78 | 1.8 | 74 | 2.0 | 4 | 0.6 | 0.35 | 0.13 to 0.97 | 0.043 | 0.53 | 0.18 to 1.50 | 0.23 |
Mode of admission | ||||||||||||
Section 3 | 4284 | 96.3 | 3546 | 96.9 | 738 | 93.5 | Ref | – | – | – | – | – |
Section 37 | 164 | 3.7 | 113 | 3.1 | 51 | 6.5 | 2.17 | 1.54 to 3.05 | <0.001 | 1.42 | 0.93 to 2.16 | 0.105 |
Adjusted models accounting for all predictor variables entered simultaneously into multiple logistic models.
CTO, community treatment order; LAI, long-acting injectable.