Phase | Measurements |
Assessments during pregnancy | Enrolment package, T1 (gwk 8–21), T2 (gwk 22–27), T3 (gwk 28–31), T4 (gwk 32–35), T5 (gwk 36–41) |
Enrolment package in pregnancy, first visit to well-baby clinic (range gwk 8–34) At well-baby clinic Web from home* | Mothers and fathers: demographic information, somatic and mental health, medication/smoking/alcohol habits (TWEAK), thoughts about unborn child, life stress (PSI-LS), relational experiences (ECR), adverse childhood experiences (ACE) Mothers only: FFQ*, hair and urine samples |
T1 (gwk 8–21) | Both parents: pregnancy anxiety concerns (PRAQ-R), depressive symptoms (EPDS), medication/smoking/alcohol habits (TWEAK), thoughts about unborn child Mothers only: brief FFQ |
T2 (gwk 22–27) Web from home | Both parents: pregnancy anxiety concerns (PRAQ-R), medication/smoking/alcohol habits (TWEAK), depressive symptoms (EPDS), thoughts about unborn child Mothers only: brief FFQ |
T3 (gwk 28–31) At well-baby clinic | Both parents: pregnancy anxiety concerns (PRAQ-R), medication/smoking/alcohol habits (TWEAK), depressive symptoms (EPDS), thoughts about unborn child Mothers only: brief FFQ, blood, urine and hair samples |
T4 (gwk 32–35) Web from home | Both parents: pregnancy anxiety concerns (PRAQ-R), medication/smoking/alcohol habits (TWEAK), depressive symptoms (EPDS), thoughts about unborn child Mothers only: FFQ |
T5 (gwk 36–41) Web from home | Both parents: pregnancy anxiety concerns (PRAQ-R), medication/smoking/alcohol habits (TWEAK), depressive symptoms (EPDS), thoughts about unborn child Mothers only: brief FFQ |
T6 birth | Birth weight; gestational age; birth complications |
Follow-up
At well-baby clinic Web from home* | T7 6 weeks, T8 6 months, T9 12 months, T10 18 months |
T7 child age 6 weeks At well-baby clinic Web from home* | Infant-mother assessment procedure (MABI) Infants: diurnal rhythm; DNA extracted from saliva, infant hair samples Mothers: FFQ*, child nutrition and breast feeding*, maternal hair and urine samples Both parents: depressive symptoms (EPDS) |
T8 child age 6 months At well-baby clinic Web from home* | Infants: infant development (Bayley Scales, screening test†); infant social withdrawal behaviour (ADBB); hair and blood samples Mothers: hair, urine and blood samples, FFQ*, child nutrition and breast feeding* Both parents: PSI, infant-parent interaction, depressive symptoms (EPDS), perceived infant temperament* (Cameron-Rice‡) |
T9 child age 12 months At well-baby clinic Web from home* | Infants: infant development (Bayley Scales, screening test†), infant social withdrawal behaviour (ADBB), genetic information extracted from saliva, infant hair and blood samples Mothers: FFQ*, child nutrition and breast feeding*, maternal hair, urine and blood samples Both parents: PSI, infant-parent interaction, depressive symptoms (EPDS), perceived infant temperament* (Cameron-Rice‡) |
T10 child age 18 months At well-baby clinic Web from home* Web from child care centres¶ | Infants: infant development (Bayley Scales, full scale§), infant social withdrawal behaviour (ADBB), infant hair and urine samples Mothers: maternal hair and urine samples Both parents: PSI, infant-parent interaction, depressive symptoms (EPDS), child social emotional assessment* (ITSEA) Childcare centre: child social emotional assessment¶ (ITSEA) |
*Web from home.
†Bayley Scales of Infant and Toddler Development, screening test.46
‡Cameron-Rice perceived temperament scale.48
§Bayley Scales of Infant and Toddler Development, full scale.46
¶Web from child care centres.
ACE, Adverse Childhood Experiences Scale10; ADBB, Alarm Distress Baby Scale47; ECR, Experiences in Close Relationships Scale37; EPDS, Edinburgh Postnatal Depression Scale34; FFQ, Food Frequency Questionnaire43 44; gwk, gestational week; ITSEA, Infant-Toddler Social and Emotional Assessment50; MABI, Mothers’s Assessment of the Behaviour of the Infant45; PRAQ-R, Pregnancy-Related Anxiety Questionnaire-Revised40; PSI, Parenting Stress Index36; PSI-LS, Parenting Stress Index-Life Stress36; TWEAK, Tolerance, Worried, Eye-opener, Amnesia, Cut-down.