Table 2

Results of four sensitivity analysis by separate COX proportional regression models among patients with acute myocardial infarction or heart failure in whom the relevant data point were available. Model 1, propensity-score matched patients with available data on BMI; model 2, propensity-score matched patients with available data on LVEF; model 3, propensity-score matched patients with available data on LDL-C measured on admission or within the preceding 6 months; model 4, propensity-score matched patients with available data on sodium, BUN and creatinine levels measured on admission.

Acute myocardial infarction
VariablesModel 1
HR (95% CI) p value
Model 2
HR (95% CI) p value
Model 3
HR (95% CI) p value
Model 4
HR (95% CI) p value
Age1.06 (1.05 to 1.06)<0.00011.07 (1.06 to 1.07)<0.00011.06 (1.05 to 1.06)<0.00011.06 (1.05 to 1.06)<0.0001
Gender1.06 (0.99 to 1.14) 0.11231.04 (0.96 to 1.13) 0.31281.07 (0.99 to 1.14) 0.06501.07 (0.96 to 1.11) 0.3931
Ethnicity0.79 (0.71 to 0.89) 0.00010.76 (0.65 to 0.89) 0.00060.735 (0.67 to 0.87) 0.92860.83 (0.75 to 0.92) 0.0003
Length of stay 1.01 (1.01 to 1.02)<0.00011.01 (1.01 to 1.02)<0.00011.02 (1.01 to 1.02)<0.00011.00 (0.99 to 1.01) 0.1374
Cancer versus no cancer1.82 (1.62 to 2.05)<0.00012.08 (1.82 to 2.39)<0.00011.77 (1.57 to 1.99)<0.00011.76 (1.56 to 1.99)<0.0001
CKD versus no CKD1.67 (1.49 to 1.86)<0.00011.88 (1.66 to 2.13)<0.00011.47 (1.31 to 1.64)<0.0001
COPD versus no COPD1.64 (1.50 to 1.81)<0.00011.78 (1.60 to 1.98)<0.00011.75 (1.60 to 1.91)<0.00011.58 (1.44 to 1.74)<0.0001
DM versus no DM1.48 (1.37 to 1.60)<0.00011.51 (1.51 to 1.39)<0.00011.45 (1.35 to 1.56)<0.00011.38 (1.28 to 1.49)<0.0001
HLP versus no HLP0.74 (0.70 to 0.80)<0.00010.77 (0.72 to 0.83)<0.00010.76 (0.71 to 0.82)<0.0001
HF versus no HF1.65 (1.52 to 1.78)<0.00011.54 (1.40 to 1.69)<0.00011.65 (1.54 to 1.78)<0.00011.55 (1.43 to 1.68)<0.0001
HTN versus no HTN0.96 (0.89 to 1.03) 0.30221.01 (0.93 to 1.09) 0.87350.95 (0.89 to 1.02) 0.15320.85 (0.79 to 0.91)<0.0001
Stroke versus no stroke1.32 (1.12 to 1.57) 0.00041.20 (0.98 to 1.46) 0.07351.28 (1.09 to 1.51) 0.00601.45 (1.23 to 1.71)<0.0001
BMI0.99 (0.98 to 0.99) 0.0130
LVEF <50% versus≥50%1.36 (1.26 to 1.48)<0.0001
Sodium,≤135 versus>135 mmol/L1.12 (1.03 to 1.22) 0.0055
BUN ≤19 versus≥20 mg/dL0.79 (0.73 to 0.85)<0.0001
Creatinine≤1.5 versus>1.5 mg/dL0.66 (0.55 to 0.66)<0.0001
LDL-C, Q2 versus Q10.90 (0.83 to 0.99) 0.0240
LDL-C, Q3 versus Q10.87 (0.79 to 0.95)<0.0033
LDL-C, Q4 versus Q10.83 (0.75 to 0.92)<0.0003
HF
VariablesModel 1
HR (95% CI) p value
Model 2
HR (95% CI) p value
Model 3
HR (95% CI) p value
Model 4
HR (95% CI) p value
Age1.03 (1.03 to 1.04)<0.00011.04 (1.04 to 1.05)<0.00011.03 (1.03 to 1.04)<0.00011.04 (1.03 to 1.04)<0.0001
Gender1.10 (1.03 to 1.19) 0.00101.11 (1.01 to 1.21) 0.02641.07 (0.98 to 1.15) 0.11441.02 (0.93 to 1.11)<0.0001
Ethnicity1.18 (1.04 to 1.35) 0.01191.05 (0.87 to 1.25) 0.62431.14 (1.00 to 1.31)<0.04621.13 (0.97 to 1.32) 0.1155
Length of stay1.02 (1.01 to 1.02)<0.00011.02 (1.01 to 1.02)<0.00011.02 (1.01 to 1.02)<0.00011.04 (1.01 to 1.02) 0.0005
Cancer versus no cancer1.43 (1.30 to 1.57)<0.00011.44 (1.28 to 1.62)<0.00011.34 (1.19 to 1.49)<0.00011.41 (1.25 to 1.59)<0.0001
CKD versus no CKD1.50 (1.39 to 1.62)<0.00011.72 (1.56 to 1.89)<0.00011.48 (1.36 to 1.62)<0.0001
COPD versus no COPD1.16 (1.07 to 1.26) 0.00041.25 (1.13 to 1.39)<0.00011.19 (1.08 to 1.30) 0.00021.23 (1.11 to 1.36)<0.0001
DM versus no DM1.14 (1.06 to 1.23) 0.00051.13 (1.03 to 1.23) 0.00681.08 (1.00 to 1.17) 0.04501.08 (0.99 to 1.18) 0.0769
HLP versus no HLP0.81 (0.76 to 0.87)<0.00010.83 (0.76 to 0.90)<0.00010.78 (0.72 to 0.85)<0.0001
CAD versus no CAD1.03 (0.96 to 1.10) 0.41441.04 (0.96 to 1.14) 0.34571.02 (0.94 to 1.11) 0.58541.05 (0.96 to 1.14) 0.2684
HTN versus no HTN0.97 (0.90 to 1.05) 0.42290.99 (0.90 to 1.08) 0.80290.95 (0.87 to 1.03) 0.20730.83 (0.85 to 1.02) 0.1386
Stroke versus no stroke1.05 (0.86 to 1.28) 0.62731.17 (0.94 to 1.46) 0.16051.06 (0.86 to 1.30) 0.58121.01 (0.80 to 1.28) 0.9253
BMI0.99 (0.98 to 0.99)<0.0001
LVEF <50% versus≥50%1.07 (0.98 to 1.17) 0.1328
Sodium,≤135 versus>135 mmol/L1.35 (1.23 to 1.48)<0.0001
BUN ≤19 versus≥20 mg/dL0.83 (0.74 to 0.92) 0.0007
Creatinine <1.5 versus≥1.5 mg/dL0.76 (0.70 to 0.84)<0.0001
LDL-C, Q2 versus Q10.89 (0.81 to 0.98) 0.0197
LDL-C, Q3 versus Q10.82 (0.74 to 0.92)<0.0003
LDL-C, Q4 versus Q10.77 (0.68 to 0.87)<0.0001
  • BMI, body mass index; BUN, blood urea nitrogen; CAD, coronary artery disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; HF, heart failure; HLP, hyperlipidemia; HTN, hypertension; LDL-C, low-density lipoprotein cholesterol; LVEF, left ventricular ejection fraction; Q, quartile.