Tabular listing of schedule of events and assessments and procedures of the study
| Study periods | Before surgery | Surgery | Discharge from hospital | 90-day follow-up | 12-month follow-up |
| Visit | 1 | 2 | 3 | 4 | 5 |
| Time (days) | 0 (-7–0) | 0 | 5 (3–14) | 90 (±10) | 365 (±30) |
| Patient information and informed consent | x | (x) | (x) | ||
| Demographics | x | ||||
| Medical history | x | ||||
| Inclusion /exclusion criteria | x | ||||
| Physical examination | x | x | x | ||
| Laboratory examinations | |||||
| Quick/INR/PTT Thrombocyte count | x x | ||||
| Randomisation | x | ||||
| Other examinations (CT scan) Haematoma volume | x x | x x | x x | ||
| Administer medical device (burr hole covers and screws) | x | ||||
| Primary outcome | |||||
| Patient satisfaction (ANA) | x | x | |||
| Secondary outcomes | |||||
| Impairment in ADLs | x | x | |||
| Skin depression | x | x | |||
| HrQoL (EQ-5D) | x | x | x | ||
| Disability (mRS) | x | x | x | ||
| Neurological status (NIHSS) | x | x | x | ||
| Complications (CDG) | x | x | x | ||
| Adverse events | x | x | x | x B | x |
ADLs, activities of daily living; ANA, Aesthetic Numeric Analogue; CDG, Clavien-Dindo Grading; EQ-5D, euroQol five dimension; HrQol, health-related quality of life; INR, international normalised ratio; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; PTT, partial thromboplastin time.