Table 1

Inclusion and exclusion criteria for haemophilia a carriers

Inclusion	Exclusion
Symptomatic haemophilia A carriers defined as a Self-BAT Score ≥6. Symptomatic haemophilia A carriers ≥50 years old. (a) Confirmed diagnosis of carriership through genetic factor VIII sequencing. (b) Or women who have appropriate family history (daughter of a man with haemophilia or mother of two sons with haemophilia or mother of one son with haemophilia and at least one other affected male relative). All affected men must have a confirmed diagnosis through genetic screening factor VIII sequencing (from standard of care).	Under the age of 50 years. Women who are pregnant or lactating. Diagnosed with another bleeding disorder (eg, von Willebrand disease). Participants with a previous diagnosis of hepatitis C virus (HCV) or HIV. Participants with a history of: kidney failure, Cushing’s disease, liver impairment, anorexia and/or bulimia, rheumatoid arthritis, obstructive pulmonary disease, scurvy. Participants on bisphosphonate therapy, chronic steroid use, or anti-resorptive therapy.

Inclusion

Exclusion

Symptomatic haemophilia A carriers defined as a Self-BAT Score ≥6.
Symptomatic haemophilia A carriers ≥50 years old.
(a) Confirmed diagnosis of carriership through genetic factor VIII sequencing.
(b) Or women who have appropriate family history (daughter of a man with haemophilia or mother of two sons with haemophilia or mother of one son with haemophilia and at least one other affected male relative).
All affected men must have a confirmed diagnosis through genetic screening factor VIII sequencing (from standard of care).

Under the age of 50 years.
Women who are pregnant or lactating.
Diagnosed with another bleeding disorder (eg, von Willebrand disease).
Participants with a previous diagnosis of hepatitis C virus (HCV) or HIV.
Participants with a history of: kidney failure, Cushing’s disease, liver impairment, anorexia and/or bulimia, rheumatoid arthritis, obstructive pulmonary disease, scurvy.
Participants on bisphosphonate therapy, chronic steroid use, or anti-resorptive therapy.