Table 3

Construct validity assessment for preclinical studies

First author, yearAdult usedAnimals with advanced stage diseaseAnimals immune to HSVXenograft model usedUsed model with a Humanised immune system
Cooke, 201624 UnclearNoUnclearNoUnclear
Cooke, 201522 UnclearNoUnclearNoUnclear
Piasecki, 201523 UnclearUnclearUnclearNoUnclear
Piasecki, 201321 UnclearUnclearUnclearNoUnclear
Liu, 200320 UnclearNoYesNoUnclear
  • HSV, Herpes Simplex Virus.