Table 3

Subgroup analysis of the crude and adjusted HR (95% CI) of mood disorder for spine fracture according to age and sex

CharacteristicHR (95% CI)
Crude*P valueAdjusted*†P value
Young men (20–39 years old, n=33 515)
 Mood disorder1.69 (1.11 to 2.57)0.014‡1.30 (0.84 to 2.01)0.236
 Control1.001.00
Young women (20–39 years old, n=64 200)
 Mood disorder1.77 (1.29 to 2.43)<0.001‡1.47 (1.06 to 2.03)0.021‡
 Control1.001.00
Middle-aged men (40–59 years old, n=40 305)
 Mood disorder1.33 (1.07 to 1.67)0.012‡1.16 (0.92 to 1.46)0.202
 Control1.001.00
Middle-aged women (40–59 years old, n=78 420)
 Mood disorder1.31 (1.16 to 1.49)<0.001‡1.14 (1.00 to 1.30)0.049‡
 Control1.001.00
Old men (60+ years old, n=29 185)
 Mood disorder1.43 (1.24 to 1.64)<0.001‡1.27 (1.10 to 1.47)0.001‡
 Control1.001.00
Old women (60+ years old, n=55 075)
 Mood disorder1.14 (1.07 to 1.22)<0.0011.03 (0.96 to 1.10)0.402
 Control1.001.00
  • *Stratified the model for age, income, region of residence and osteoporosis.

  • †Adjusted the model for the Charlson Comorbidity Index and history of Alzheimer’s dementia.

  • ‡Cox proportional hazards regression model; significance at p<0.05.