Overview of study visits
| Visit | V0 | V1
Randomisation | T1 | V2 | T2 | V3 |
| Time, weeks | −4±1 | 0±1 | 2±1 | 4±1 | 8±1 | 12±1 |
| Inclusion/exclusion criteria | X | X | ||||
| Medical history | X | |||||
| Informed consent | X | |||||
| Blood samples, non-fasting | X | X | ||||
| Physical examination | X | X | ||||
| Adverse events | X | X | X | X | X | |
| Endpoints, main study | ||||||
| 82Rb-PET (primary endpoint) | X | X | ||||
| Echocardiography | X | X | ||||
| Ambulatory BP | X | X | ||||
| Adipose tissue biopsy | X | X | ||||
| Oral glucose tolerance test | X | X | ||||
| Questionnaires | X | X | ||||
| HRV | X | X | ||||
| PWA | X | X | ||||
| 51Cr EDTA clearance | X | X | ||||
| Body composition (DXA) | X | X | ||||
| Blood samples, fasting | X | X | ||||
| Urine samples, fasting | X | X | ||||
| Endpoints, substudy | ||||||
| Haemodynamics (key secondary endpoint) | X | X | ||||
| Accelerometer | X | X | ||||
X marks that the given examination will be performed at the specific visit.
BP, blood pressure; HRV, heart rate variability; PWA, pulse wave analysis; 82Rb-PET, Rubidium-82 position emission tomography.