Table 1

Association between disease-modifying therapy dispensations and healthcare utilisation in the multiple sclerosis cohort in Saskatchewan

Variable	Risk ratio	95% CI	P value
All-cause hospitalisations*
Per 1000 DMT dispensations	0.994	0.992 to 0.996	<0.0001
Calendar year	0.978	0.974 to 0.983	<0.0001
MS-specific hospitalisations*
Per 1000 DMT dispensations	0.909	0.880 to 0.938	<0.0001
Calendar year	0.940	0.924 to 0.957	<0.0001
All-cause hospitalisations†	1.000	1.000 to 1.000	0.090
All-cause mean length of stay (days)‡
Per 1000 DMT dispensations	1.077	1.024 to 1.132	0.004
Calendar year	0.999	0.993 to 1.005	0.781
All-cause physician claims*
Per 1000 DMT dispensations	1.006	0.990 to 1.022	0.477
Calendar year	0.982	0.977 to 0.987	<0.0001
MS-specific physician claims*
Per 1000 DMT dispensations	0.962	0.910 to 1.016	0.165
Calendar year	0.954	0.935 to 0.975	<0.0001

*Negative binomial regression fitted with generalised estimating equation (GEE).
†Adjusted for all-cause hospitalisations in the Saskatchewan general population to account for changes in hospitalisation trends.
‡Poisson regression fitted with GEE.
DMT, disease-modifying therapy; MS, multiple sclerosis.