Table 1

Studies and case reports addressing colonisation of proximal intestinal remnant in infants with enterostomy

Underlying conditionType of studyAimSample sizeResultsReference
CMGIT, NEC and SIPRandomised controlled trialTo determine the effect of an enteral oil supplementation on the intestinal microbiomen=32 preterm infants (n=16 in each group)Enrichment of many genera from Enterobacteriaceae family, including Escherichia, Pantoea, Serratia and Citrobacter over time, in infants receiving standard nutritional therapy.
Enteral oil supplementation increased bacterial diversity and decreased the abundance of pathogenic bacteria.
SIP and NECCase reportTo study microbiota diversity according to the length of remnant intestinen=2 preterm infantsHuman infant ileum and colon are dominated by Bifidobacterium. 16
CMGIT and SIPCase reportTo quantify Lactobacillus and Bifidobacterium probiotic strains in the neonatal ileumn=2 (1 preterm and 1 term infant) Lactobacillus and Bifidobacterium strains were identified in the neonatal ileum. 17
CMGITCase reportTo study the effect of probiotic therapy after CMGIT surgeryn=2 (1 preterm and 1 term infant)Probiotic therapy with Lactobacillus casei and Bifidobacterium breve was effective and these strains became well established in the intestine. 14
CMGIT, NEC and SIPObservational studyTo compare the microbiota composition in fresh intestinal tissue collected during surgery vs faecal samplesn=7 preterm or term infantsIntestinal bacteria diversity was higher in the intestinal tissue and in faecal samples adherent to the intestinal mucosa. 15
  • CMGIT, congenital malformation of the gastrointestinal tract; NEC, necrotising enterocolitis; SIP, spontaneous intestinal perforation.