Group A only: Separate screening visit prior to the study visit to check that the participants meet the eligibility criteria; full medical history, physical examination, blood pressure and blood tests (full blood count, Glucose, glycated haemoglobin and renal function) | |
Time of day | Procedures/assessments* |
Morning | Eligibility check |
Informed consent | |
Demographic data (date of birth, sex, ethnicity, height and weight) | |
Relevant clinical history | |
Current medications | |
Blood pressure and heart rate | |
Pulse wave velocityto measure arterial resistance | |
Laser Dopplerto measure microvascular function | |
Blood tests: full blood count, renal function and electrolytes, liver function tests, NT-proBNP, high-sensitive cardiac troponin T. Samples will be frozen and stored for future analysis of vascular and other biomarkers, for example, galectin-3. | |
Urine test:albumin and creatinine. samples will be frozen and stored for future analysis of metabolite profiles. | |
Lunch | |
Afternoon | Transthoracic echocardiography: tissue Doppler imaging and strain rate imaging |
6 min walk test | |
Cardiopulmonary exercise test |
All assessments will be aimed to be completed in a single visit. However, a possible second visit may be arranged either at Atrium Health or University Hospitals Coventry and Warwickshire NHS Trust for completion of all assessments, if required.