Table 2

Characteristics of included studies that did not directly compare effect of comorbidity to OHCA outcome

Study IDCountryStudy designCasesEnrolment
Period		Reported outcomeComorbiditySource of comorbidity dataInclusion criteriaAge
(years)
Beitland et al 201628 NorwayProspective cohort245Sept 2010–Jan 2014Survival with good neurological outcome at 6 months.Diabetes (type II) and chronic hypertension.Hospital recordsAll patient with GCS <8 on admission who received TTM within 24 hours of ICU stay.≥18
Bro-Jeppesen et al 201229 DenmarkProspective cohort360Jun 2004–Dec 201030-day mortality.No comorbidities.UnclearAll patients admitted to hospital with ROSC, GCS <9 and no cardiogenic shock.≥18
Chen et al 201726 TaiwanRetrospective cohort53382005–2012Survival to hospital discharge.CCI=1, ≥2, angina, tumour, acute myocardial infarction, cerebrovascular disease, congestive heart failure, coronary artery disease, diabetes.Taiwan National Health Insurance databaseAll non-traumatic OHCA patients admitted to the emergency department.≥18
Eid et al 201741 USACross sectional247 6841995–2013Neurological outcome at hospital discharge.mCCI=1, 2, 3, ≥4.Nationwide Inpatient Survey (NIS)All OHCA patients (non-traumatic) who achieved ROSC and were hospitalised.≥18
Fabbri et al 200633 ItalyProspective cohort479Jul 1994– Dec 2004Neurological outcome at discharge.Hypertension, diabetes, congestive cardiac failure, myocardial infarction.UnclearAll bystander witnessed OHCA of presumed cardiac origin.≥18
Oh et al 201843 KoreaRetrospective cohort295Mar 2007–Dec 2013Neurological outcome (CPC).Non-diabetic.Registry and electronic recordsAll OHCA patients who achieved ROSC and were admitted to the emergency intensive care unit and were administered therapeutic cooling.≥18
Sharma et al 201636 NetherlandsRetrospective cohort195Mar 2012–Apr 2014Survival to hospital discharge.Atrial fibrillation, cerebrovascular accident, congestive heart failure, diabetes, dyslipidaemia/cardiovascular conditions, hypertension, myocardial infarction, ventricular fibrillation.Hospital recordsOHCA of cardiac presumed cardiac origin in patients that survived to emergency department admission (survived means either in ROSC or ongoing CPR).Adults
Søholm et al 201437 DenmarkProspective cohort10162007–201130-day mortality.CCIHospital recordsAll OHCA of any aetiology where patient was either in ROSC or had ongoing CPR on emergency department admission.>18

  • CCI, Charlson Comorbidity Index; CPC, cerebral performance category; CPR, cardiopulmonary resuscitation; DNR, do not resuscitate; EMS, emergency medical services; GCS, Glasgow Coma Scale; ICU, intensive care unit; OHCA, out-of-hospital cardiac arrest; ROSC, return of spontaneous circulation; TTM, therapeutic temperature management; VF, ventricular fibrillation; VT, ventricular tachycardia.