Table 1

Inclusion and exclusion criteria

InclusionExclusion
ParticipantsParticipants with symptomatic (A) carotid stenosis (B)
  1. Symptomatic is defined as ipsilateral TIA or minor stroke within 6 months.

  2. Carotid stenosis is defined as greater than 50% stenosis (or the equivalent measurement).

Participants with asymptomatic carotid stenosis, carotid artery occlusions, carotid near-occlusion, concomitant coronary bypass surgery and redo surgeries for carotid stenosis
InterventionsManagement by endarterectomy and/or stentingIntervention done for tandem occlusions in the setting of acute ischaemic stroke, redo interventions, concomitant interventions with other surgery, comparisons of types or approaches for the same intervention
ComparatorsMedical therapy, endarterectomy and stenting
OutcomesPrimary outcomes: composite of any stroke or death at 30 days
Secondary outcomes:
  1. 30-day disabling stroke or death, myocardial infarction, different types of stroke. Disabling stroke is defined as any stroke resulting in new or increased disability with a score on the modified Rankin Scale (mRS) of 3 or greater, 30 days or more after stroke onset.

  2. Intermediate and long-term outcome, including stroke recurrence, death and rates of restenosis according to individual studies’ prespecified outcomes

TimingStudies published from 1990 onwards.
Study designRandomised controlled trials (RCT), meta-analysis or systematic reviews reporting individual patient data from RCTsSystematic reviews/meta-analysis, observational studies (eg, cohorts, case–controls, cross sections), case series/reports and non-empirical studies (eg, editorials, comments, letters)
LanguageEnglish and French
  • TIA, transient ischaemic attack.