Table 1

Summary of included SRs

Author (year)AimSearch periodNumber of studies includedTypes of studies included in reviewJurisdictions of included studies (n studies)
Krauer et al (2017)15 To assess the relationship between ZIKV infection and congenital brain abnormalities and Guillain-Barré syndromeFrom inception until 30 May 2016106Case reports, case series, case–control studies, cohort studies, cross-sectional studies, ecological study/outbreak reports, modelling studies, animal experiments, in vitro experiments, sequence analysis and phylogeneticsBrazil (6), Cabo Verde (2), Colombia (1), French Polynesia (2), Martinique (2), Panama (5), El Salvador (1), Haiti (119), Puerto Rico (1), Venezuela (1), Slovenia*, Netherlands*, Dominican Republic*, French Guiana*, Honduras*, Paraguay*, Suriname*, Micronesia*, Pacific Islands*
Paixão et al (2016)16 To summarise current knowledge on ZIKV including epidemiology, clinical presentation and complications1954 to January 201641Case reports, case series, surveillance reports, cross-sectional studies, epidemiological bulletins and alertsNot clearly reported
Most data are from Brazil and French Polynesia
Chibueze et al (2017)17 To summarise guidance on pregnancy care in the context of ZIKV infectionFrom inception until 3 March 201618Case reports, case series, observational studiesBrazil (11)
Colombia (1)
France (1)
Puerto Rico (1)
Slovenia (1)
USA (2)
Venezuela (1)
Coelho et al (2017)18 To summarise evidence and meta-analyse data to estimate prevalence of microcephaly in babies born to ZIKV-infected pregnant womenNot reported8Cohort studiesBrazil (1)
Colombia (1)
French Guiana (1)
Puerto Rico (1)
USA (4)
Simões et al (2016)19 To assess the effects of ZIKV infection on during pregnancy and postpartum periodsFrom inception until 23 February 201630Case reports, case series, guidelinesNot clearly reported; most data are from Brazil
Padilla et al (2016)20 To review clinical and basic science literature about ZIKV infection relevant for obstetric anesthesiologistsFrom inception until 15 April 201630SRs, narrative reviews, case reports, epidemiological studies, government reports and news articlesNot clearly reported
Marques et al (2019)21 To map the neurological damage and outcomes related to congenital ZIKV infectionJanuary 1966 to August 201828Not informedBrazil (16)
USA (3)
Colombia (1)
Counotte et al (2018)22 To summarise the evidence of the casual associations between ZIKV and CZS and GBS30 May 2016 to 18 January 2017101Case report, case series, case–control study, cohort study, cross-sectional study, controlled trials, ecological study/outbreak report, modelling study, animal experiment, in vitro experiment, sequencing and phylogenetics, biochemical/protein structure studiesUSA, Martinique, Brazil, Suriname, Colombia, French Guiana, Slovenia, Spain, Uganda, Nicaragua, Barbados, Belize, Dominican Republic, El Salvador, Guatemala, Haiti, Honduras; Mexico, Republic of Marshall Islands, Venezuela, French Polynesia, Ecuador, France, Puerto Rico, Guadeloupe, Guyana, New Zealand, French Southern Territories.
Haby et al (2018)23 To estimate and meta-analyse the prevalence of asymptomatic ZIKV infection in the general population and in specific population groups from observational epidemiological studiesFrom inception until 26 January 201823Cross-sectional seroprevalence studies, case series, case–control, cohortUSA (6), Brazil (3), French Polynesia (3), French Guiana (3), Puerto Rico (2), Colombia (2), Spain (2), Micronesia (1), Martinique (1)
Sarwar et al (2018)24 To report on the current literature regarding ZIKV and its hazardous effects on maternofetal health with a special emphasis on risk assessment, virus transmission, associated complications and possible management2007 to May 201769Not informedArgentina, Bolivia, Brazil, Colombia, French Guiana, Suriname, Paraguay, Trinidad and Tobago, Canada, Dominican Republic, Grenada, Guadeloupe, Guatemala, Haiti, Martinique, Puerto Rico, USA, Costa Rica, El Salvador, Honduras, Nicaragua, Panama, Europe, Slovenia, Spain, Thailand, Vietnam, French Polynesia, Marshall Islands, Cape Verde.
Wahid et al (2018)25 To summarise the evidence of neurological complications in ZIKV-infected people2015 to March 201735Case-studies, case-cohort studies, cross-sectional studies, organisational survey reports and case–control studiesBrazil (15)
French Polynesia (3)
Colombia (3)
USA, Slovenia, Suriname, Spain, Haiti, Martinique, Netherlands, Ecuador, Guyana (1)
Soriano-Arandes et al (2018)26 To summarise the new evidence in aspects of epidemiology, virology, pathogenesis, associated risk factors during pregnancy, newborn phenotypic signs, neuroimaging, laboratory diagnosis, treatment and vaccinesFrom inception until 30 November 2017106Case series, cohort (prospective/retrospective), cross-sectional or case-control studiesBrazil, French Polynesia, USA, Martinique, Colombia
Barbi et al (2018)27 To systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individualsFrom inception until November 20173Case series, epidemiological surveys, cross-sectional or cohort studiesFrench Polynesia (1), Suriname and Dominican Republic (1), South American, Central American and Caribbean countries (1)
Santos et al (2018)28 To analyse the association between Zika-virus and microcephaly during the gestational periodFrom inception until December 201635Not informedBrazil
Wachira et al (2018)29 To describe the factors associated with development of GBS, both infectious and non-infectious, through an SR1 January 2007 to 30 June 201734The most common were case control, cohort and self-controlled case seriesFrench Polynesia
Pomar et al (2019)30 Present a review to describe the risks and complications of maternal and subsequent fetal infection by ZIKVJune 2009 to November 201868Not informedColombia (3), Puerto Rico (1), French Guiana (3), Brazil (1), Yap Island (1), USA (2)
Wilder-Smith et al (2018)31 Describe the burden of ZIKV infection in international travellers over time; estimate the proportion of birth defects as a result of maternal ZIKV infection in travellers; track the extent of sexual transmission; summarise data on ZIKV cases in travellers identifying counties with reports on local transmission1947 to April 201765Surveillance reports, case reports, retrospective (multicentre study), descriptive retrospective analysis and prospective cohort studyUSA (9), Canada (2), Germany (3), Norway (1), France (5), Italy (7), Japan (2), Australia (4), New Caledonia (1), Finland (1), Mexico (1), Slovenia (1), Netherlands (4), Belgium (1), Portugal (1), Switzerland (3), Israel (1), Taiwan (2), Spain (1), China (7), South Korea (2), UK (2), Singapore (1), Malaysia (1)USA (9), Canada (2), Germany (3), Norway (1), France (5), Italy (7), Japan (2), Australia (4), New Caledonia (1), Finland (1), Mexico (1), Slovenia (1), Netherlands (4), Belgium (1), Portugal (1), Switzerland (3), Israel (1), Taiwan (2), Spain (1), China (7), South Korea (2), UK (2), Singapore (1), Malaysia (1)USA (9), Canada (2), Germany (3), Norway (1), France (5), Italy (7), Japan (2), Australia (4), New Caledonia (1), Finland (1), Mexico (1), Slovenia (1), Netherlands (4), Belgium (1), Portugal (1), Switzerland (3), Israel (1), Taiwan (2), Spain (1), China (7), South Korea (2), UK (2), Singapore (1), Malaysia (1)
Nithiyanantham et al (2019)32 To conduct an SR and meta-analysis on the prevalence of congenital Zika-related disorders in infants of mothers infected with ZIKV during pregnancyFrom inception until 31 October 201725Case series, epidemiological reports, prospective and retrospective studies, cohort studies and cross-sectional studiesUSA (8), Brazil (6), Colombia (2), Puerto Rico (1), French Polynesia (1), Martinique (1), Trinidad and Tobago (1), French Guiana (1), Ecuador (1), Spain (1)
Masel et al (2019)33 To determine if prior infection with DENV, as compared with those with no prior DENV infection, is associated with a greater risk of ZIKV complications (including neurological and teratogenic outcomes), greater ZIKV peak viremia, greater area-under-the-curve of viremia or other putative laboratory proxies of ZIKV severityFrom inception until 25 March 20185Case–control studyBrazil (2), French Polynesia (5)
Barbosa et al (2019)34 To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired ZIKV infectionFrom inception until April 201927Case report and case seriesBrazil (14), Colombia (3), USA (2), French Polynesia (1), Puerto Rico (1)
Minhas et al (2017)35 Focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseasesFrom inception until March 20173Case report and prospective observational multicentre studyFrance (1), Venezuela (1), China (1)

  • *Not possible to know number of studies from these countries.

  • GBS, Guillain-Barré syndrome; SR, systematic review; ZIKV, Zika virus.