Table 1

Financial implications of switching from MDIs to DPIs

Inhaler type (and most common example)Number prescribed in 2017Total cost of this type of inhaler (£)Cheapest DPI alternativeCost (£) change with proportional replacement (per 10%)Cost (£) change with cheapest replacement (per 10%)
SABA (salbutamol MDI)21 930 62558 195 683.24Salbutamol 100 Easyhaler3 068 201.993 042 770.28
LABA (salmeterol 25 MDI)700 14525 250 958.95Formoterol Easyhaler1 474 723.02−1 018 957.21
Very low dose ICS (Clenil modulite 50)887 3423 814 625.02Flixotide Accuhaler 50, one inhalation twice a day875 534.13875 534.13
Low dose ICS (Clenil modulite 100)3 874 07736 581 577.50Beclometasone Easyhaler 200, one inhalation twice a day2 461 791.16−213 579.26
Medium dose ICS (Clenil modulite 200)1 683 46634 611 159.90Beclometasone Easyhaler 200, two inhalations twice a day3 828 332.15−628 752.90
High dose ICS (Clenil modulite 250)287 6047 923 785.74Budesonide Easyhaler 400, two inhalations twice a day1 084 787.73173 464.97
Low dose ICS+LABA (Seretide 50 Evohaler)1 181 94132 582 876.16Duoresp Spiromax 160/4.5, one inhalation twice a day749 613.82121 485.45
Medium dose ICS+LABA (Fostair 100/6 MDI)9 467 562373 045 012.90Relvar Ellipta 92/, one inhalation once a day3 124 173.89−4 876 327.15
OR Fostair 100/6 Nexthaler two inhalations twice a dayOR −1 123 070.10
High dose ICS+LABA (Seretide 250 Evohaler)3 425 542184 212 379.80Fostair 200/6 Nexthaler two inhalations twice a day−4 541 648.60−5 248 427.76
ICS+LAMA+LABA (Trimbow)5211247 464.50Trelegy Ellipta552 801.25552 801.25
  • DPI, dry powder inhaler; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; LAMA, long-acting muscarinic antagonist; MDI, metered-dose inhalers ; SABA, short-acting beta-agonist.