Table 2

Baseline characteristics, factors associated with NEC in literature and outcomes in neonates 240–286 weeks’ gestation between 2014–2015 (patient level data)

ANZNNCNNFinMBRINNSEN
1500
SNQSwiss
NeoNet
Tuscan
NN
All
Eligible infants
(240–286 weeks), N
292629943171215215884964518511 289
Excluded infants, n (%)378 (12.9)580 (19.4)14 (4.4)43 (3.5)260 (12)144 (17)63 (9.8)15 (8.1)1497 (13.3)
Study population, N25482414303117218987055821709792
Baseline characteristics
 Gestational age, mean (SD)26.4 (1.4)26.3 (1.4)26.5 (1.3)26.4 (1.4)26.5 (1.3)26.4 (1.4)26.4 (1.4)26.3 (1.3)26.4 (1.4)
 Birth weight z-score, mean (SD)0.03 (0.97)−0.04 (0.86)−0.04 (0.93)−0.01 (0.93)−0.11 (0.99)−0.17 (0.86)−0.22 (0.85)0.18 (0.99)−0.05 (0.93)
 SGA, n (%)264 (10.4)220 (9.1)32 (10.6)110 (9.4)243 (12.8)76 (10.8)69 (11.9)15 (8.8)1029 (10.5)
 Multiple births, n (%)691 (27.1)628 (26.0)88 (29.0)419 (35.8)568 (29.9)188 (26.7)171 (29.4)61 (35.9)2814 (28.7)
 Male, n (%)1385 (54.4)1241 (51.5)164 (54.1)639 (54.5)1000 (52.7)404 (57.3)320 (55.0)94 (55.3)5247 (53.6)
NEC associated factors
 Antenatal steroid, n (%)2419 (95.7)2266 (94.7)293 (97.3)972 (82.9)1761 (92.9)614 (87.1)546 (93.8)156 (92.3)9049 (92.6)
 Caesarean, n (%)1531 (60.3)1444 (60.0)202 (66.7)829 (70.7)1257 (66.2)495 (70.7)481 (82.7)124 (72.9)6363 (65.1)
 PDA treated with indomethacin, n (%)NA797 (33.0)77 (25.9)327 (27.9)0* (0)0* (0)231 (39.6)0* (0)1432 (19.8)
 Sepsis, n (%)NA506 (21.0)57 (19.4)297 (27.5)864 (46.2)165 (23.4)85 (14.6)54 (36.5)2028 (28.6)
Outcomes
 NEC surgery, n (%)62 (2.4)74 (3.1)14 (4.6)42 (3.6)160 (8.4)18 (2.6)18 (3.1)9 (5.3)397 (4.1)
 NEC death, n (%)50 (2.0)56 (2.3)6 (2.0)30 (2.6)62 (3.3)10 (1.4)14 (2.4)5 (2.9)233 (2.4)
 All-cause mortality, n (%)280 (11.0)259 (10.7)33 (10.9)254 (21.7)394 (20.8)68 (9.7)91 (15.6)37 (21.8)1416 (14.5)
  • *Spain, Sweden and Tuscany only supplied ibuprofen or paracetamol to treat PDA during the study period.

  • ANZNN, Australian and New Zealand Neonatal Network; CNN, Canadian Neonatal Network; FinMBR, Finnish Medical Birth Register; INN, Israel Neonatal Network;n, number in subgroup;N, total number in group; NA, not available; NEC, necrotising enterocolitis;PDA, patent ductus arteriosus; SEN1500, Spanish Neonatal Network;SGA, Small for gestationa age; SNQ, Swedish Neonatal Quality Register; SwissNeoNet, Swiss Neonatal Network; TuscanNN, Tuscan Neonatal Network.