Time of measure, physical tests and questionnaires of the secondary outcomes
| Secondary outcomes | Measure | Time of measure |
| Physical health | ||
| Cardiorespiratory fitness | 6MWT62 | T1–T4, T6 |
| Muscle strength | STS-10, grip and leg strength63 64 | T1–T4, T6 |
| Independence in ADL | KATZ65 66 | T1, T4, T6 |
| Psychological health | ||
| General anxiety | GAD-767 | T1, T2, T4, T6 |
| Feelings of depression | PHQ-968 69 | T1, T2, T4, T6 |
| Health-related quality of life | RAND-36 V.242 | T1, T4, T6 |
| Lifestyle risk factors | ||
| Physical activity | iPAQ70 and Actigraph*71 | T1, T4, T6 |
| Obesity indices | BMI, waist to hip ratio | T1, T4, T6 |
| Smoking behaviour | Number of cigarettes per day | T1, T4, T6 |
| Economic evaluation | ||
| Healthcare use and related medical costs | iMCQ72 | T1, T4–T6 |
| Work participation† | iPCQ73 | T1, T4–T6 |
| QALYs | EQ-5D-5L52 | T1, T4–T6 |
| Potential mediators | ||
| Cardiac self-efficacy | CSE45 | T1, T2, T4, T6 |
| Illness representations | IPQ-R43 | T1, T2, T4, T6 |
*Patients are asked to wear the Actigraph during waking hours for one consecutive week.
†Health-related productivity losses of paid work and unpaid work.
ADL, activities of daily living; BMI, body mass index; CSE, cardiac self-efficacy; EQ-5D-5L, EuroQol Five-Dimensional Questionnaire; GAD-7, Generalised Anxiety Disorder 7-item scale; iMCQ, iMTA Medical Cost Questionnaire; iPAQ, International Physical Activity Questionnaire; iPCQ, iMTA Productivity Cost Questionnaire; IPQ-R, Illness Perception Questionnaire, Revised; KATZ, Katz Index of Independence in Activities of Daily Living; 6MWT, 6 min walking test; PHQ-9, Patient Health Questionnaire 9-item scale; QALY, quality-adjusted life years; RAND-36 V.2, Medical Outcome Study 36-item General Health Survey; STS-10, 10 times sit to stand test; T1, begin of waiting time; T2, 1–8 days before surgery; T3, moment that patients meet the University Medical Center Groningen discharge criteria; T4–T6, follow-up at 3, 7 and 12 months after surgery.