Table 2

A summary of previous systematic reviews on this topic area highlighting number of studies, number of participants and key findings

AuthorDateJournalNo of studiesNo of participantsFindingsRisk of biasGrade
Wang et al 27 2013British Journal of Surgery173720Triclosan-coated sutures significantly reduced SSI rate compared with standard sutures. RR 0.7 (95% CI 0.57 to 0.85).
Triclosan-coated sutures significantly reduced SSI rate in ‘clean’ and ‘clean-contaminated’ surgery.
IncludedNot included
Edmiston et al 28 2013Surgery133568Triclosan-coated sutures significantly reduced SSI rate compared with standard suture. RR 0.734 (95% CI 0.59 to 0.91).
No subgroup analysis was performed.
Not includedNot included
Daoud et al 30 2014Surgical infections154800Triclosan-coated sutures significantly reduced SSI rate compared with standard sutures. RR 0.67 (95% CI 0.54 to 0.84).
No subgroup analysis was performed.
Not includedNot included
Apisarnthanarak et al 58 2015Infection Control and Hospital Epidemiology29 (22 RCT and 7 non-RCT)11 942Triclosan-coated sutures significantly reduced SSI rate compared with standard suture. RR 0.65 (95% CI 0.549 to 0.769). RR for RCT alone 0.74 (95% CI 0.61 to 0.89).
Triclosan-coated sutures significantly reduced SSI rate for all CDC wound classifications.
Not includedNot included
Guo et al 31 2015Journal of Surgical Research135256Triclosan-coated sutures significantly reduced risk of SSI compared with standard suture. RR 0.76 (95% CI 0.65 to 0.88).
Triclosan-coated sutures significantly reduced risk of SSI in abdominal surgery. RR 0.70 (95% CI 0.63 to 0.99). There was no significant difference in cardiac and breast surgery.
IncludedNot included
Sandini et al 63 2016Medicine6 (only included elective colorectal surgery)2168Triclosan-coated sutures did not significantly reduce the risk of SSI compared with standard sutures in elective colorectal surgery. OR 0.81 (95% CI 0.58 to 1.13)IncludedNot included
Wu et al 59 2017European Journal of Microbiology and Infectious Disorders18 (13 RCTs and 5 non RCTs)7458Triclosan-coated sutures significantly reduced risk of SSI compared with standard suture in both the RCTs (OR 0.72; 95% CI 0.59 to 0.88) and the non- RCTs (OR 0.58; 95% CI 0.40 to 0.83). Triclosan-coated sutures significantly reduced the risk of SSIs in clean surgery.IncludedIncluded
de Jonge et al 32 2017British Journal of Surgery216462Triclosan-coated sutures significantly reduced risk of SSI compared with standard suture. RR 0.72 (95% CI 0.60 to 0.86).IncludedNot included
Leaper et al62 2017British Journal of Surgery34 (20 RCTs and 14 non-RCTs)16 762Triclosan-coated sutures significantly reduced risk of SSI compared with standard sutures. OR 0.61 (95% CI 0.52 to 0.73).
No significant difference in SSI rate for ‘contaminated’ or ‘dirty’ wounds
Not includedNot included
Konstantelias et al 61 2017Acta Chirurgica Belgica 201730 (19 RCTs and 11 non- RCTs)15 385Triclosan-coated sutures significantly reduced risk of SSI compared with standard suture. RR 0.68 (95% CI 0.57 to 0.81).
Triclosan-coated sutures significantly reduced risk of SSI in clean, clean-contaminated and ‘contaminated surgery’.
Not includedNot included
Henriksen et al 60 2017Hernia8 (only included studies reporting abdominal wall closure)3641Triclosan-coated sutures significantly reduced risk of SSI compared with standard suture in abdominal wall closure. OR 0.67 (95% CI 0.46 to 0.98).Not includedNot included
  • CDC, centre for disease control; RCTs, randomised controlled trials; RR, relative risk; SSIs, surgical site infections.